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Targeting IP6 signaling to destabilize homologous recombination proteins to overcome PARP inhibitor resistance.

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Title: Targeting IP6 signaling to destabilize homologous recombination proteins to overcome PARP inhibitor resistance.
Authors: Lee SG; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Department of Biological Science, Ulsan National Institute of Science and Technology, Ulsan, Korea.; Cas Cure Therapeutics, Magokjungang-ro 8 gil, Gangseo-gu, Seoul, Korea., Seo Y; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon, Korea.; Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Jeong S; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea., Chung Y; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea., Kong S; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea., Kim M; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea., Rhlee JH; Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, Korea., Um S; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Neuracle Genetics, Sanhakgwan 4F, 145 Anam-ro, Seongbuk-gu, Seoul, Korea., Mathew BP; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, Korea., Maiti S; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, Korea., Kuram MR; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, Korea., Abozeid MA; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, Korea., Park A; Korea Research Institute of Chemical Technology, Daejeon, Korea., Yoo JN; Department of Molecular Science and Technology & College of Pharmacy, Ajou University, Suwon, Korea., Khim KW; Department of Biological Science, Ulsan National Institute of Science and Technology, Ulsan, Korea., Son K; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea., Amarsanaa E; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea., Kim K; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea.; KAIST Stem Cell Center, KAIST, Daejeon, Korea., Hong S; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea., Choi J; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea., Park IB; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Korea Mouse Pheotyping Center, Seoul National University, Seoul, Korea., Lee EA; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea., Jeon JH; Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, Korea., Park JH; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; College of Veterinary Medicine, Jeonbuk ational University, Iksan, Jeonbuk, Korea., Han JS; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Neuracle Genetics, Sanhakgwan 4F, 145 Anam-ro, Seongbuk-gu, Seoul, Korea., Park CY; Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea., Kim S; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea.; KAIST Stem Cell Center, KAIST, Daejeon, Korea., Choi JH; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Department of Biological Science, Ulsan National Institute of Science and Technology, Ulsan, Korea., Hong SY; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, Korea., Seo MD; Department of Molecular Science and Technology & College of Pharmacy, Ajou University, Suwon, Korea., Lee H; Korea Research Institute of Chemical Technology, Daejeon, Korea., Lee JY; Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon, Korea. leejooyong@cnu.ac.kr., Myung K; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea. kmyung@ibs.re.kr.; Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea. kmyung@ibs.re.kr.
Source: Nature communications [Nat Commun] 2026 Apr 04; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting IP<subscript>6</subscript> signaling to destabilize homologous recombination proteins to overcome PARP inhibitor resistance.
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  Data: <searchLink fieldCode="AU" term="%22Lee+SG%22">Lee SG</searchLink>; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Department of Biological Science, Ulsan National Institute of Science and Technology, Ulsan, Korea.; Cas Cure Therapeutics, Magokjungang-ro 8 gil, Gangseo-gu, Seoul, Korea.<br /><searchLink fieldCode="AU" term="%22Seo+Y%22">Seo Y</searchLink>; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon, Korea.; Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Jeong+S%22">Jeong S</searchLink>; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.<br /><searchLink fieldCode="AU" term="%22Chung+Y%22">Chung Y</searchLink>; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.<br /><searchLink fieldCode="AU" term="%22Kong+S%22">Kong S</searchLink>; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea.<br /><searchLink fieldCode="AU" term="%22Kim+M%22">Kim M</searchLink>; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea.<br /><searchLink fieldCode="AU" term="%22Rhlee+JH%22">Rhlee JH</searchLink>; Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, Korea.<br /><searchLink fieldCode="AU" term="%22Um+S%22">Um S</searchLink>; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Neuracle Genetics, Sanhakgwan 4F, 145 Anam-ro, Seongbuk-gu, Seoul, Korea.<br /><searchLink fieldCode="AU" term="%22Mathew+BP%22">Mathew BP</searchLink>; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, Korea.<br /><searchLink fieldCode="AU" term="%22Maiti+S%22">Maiti S</searchLink>; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, Korea.<br /><searchLink fieldCode="AU" term="%22Kuram+MR%22">Kuram MR</searchLink>; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, Korea.<br /><searchLink fieldCode="AU" term="%22Abozeid+MA%22">Abozeid MA</searchLink>; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, Korea.<br /><searchLink fieldCode="AU" term="%22Park+A%22">Park A</searchLink>; Korea Research Institute of Chemical Technology, Daejeon, Korea.<br /><searchLink fieldCode="AU" term="%22Yoo+JN%22">Yoo JN</searchLink>; Department of Molecular Science and Technology & College of Pharmacy, Ajou University, Suwon, Korea.<br /><searchLink fieldCode="AU" term="%22Khim+KW%22">Khim KW</searchLink>; Department of Biological Science, Ulsan National Institute of Science and Technology, Ulsan, Korea.<br /><searchLink fieldCode="AU" term="%22Son+K%22">Son K</searchLink>; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.<br /><searchLink fieldCode="AU" term="%22Amarsanaa+E%22">Amarsanaa E</searchLink>; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.<br /><searchLink fieldCode="AU" term="%22Kim+K%22">Kim K</searchLink>; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea.; KAIST Stem Cell Center, KAIST, Daejeon, Korea.<br /><searchLink fieldCode="AU" term="%22Hong+S%22">Hong S</searchLink>; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea.<br /><searchLink fieldCode="AU" term="%22Choi+J%22">Choi J</searchLink>; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea.<br /><searchLink fieldCode="AU" term="%22Park+IB%22">Park IB</searchLink>; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Korea Mouse Pheotyping Center, Seoul National University, Seoul, Korea.<br /><searchLink fieldCode="AU" term="%22Lee+EA%22">Lee EA</searchLink>; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.<br /><searchLink fieldCode="AU" term="%22Jeon+JH%22">Jeon JH</searchLink>; Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, Korea.<br /><searchLink fieldCode="AU" term="%22Park+JH%22">Park JH</searchLink>; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; College of Veterinary Medicine, Jeonbuk ational University, Iksan, Jeonbuk, Korea.<br /><searchLink fieldCode="AU" term="%22Han+JS%22">Han JS</searchLink>; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Neuracle Genetics, Sanhakgwan 4F, 145 Anam-ro, Seongbuk-gu, Seoul, Korea.<br /><searchLink fieldCode="AU" term="%22Park+CY%22">Park CY</searchLink>; Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea.<br /><searchLink fieldCode="AU" term="%22Kim+S%22">Kim S</searchLink>; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea.; KAIST Stem Cell Center, KAIST, Daejeon, Korea.<br /><searchLink fieldCode="AU" term="%22Choi+JH%22">Choi JH</searchLink>; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Department of Biological Science, Ulsan National Institute of Science and Technology, Ulsan, Korea.<br /><searchLink fieldCode="AU" term="%22Hong+SY%22">Hong SY</searchLink>; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, Korea.<br /><searchLink fieldCode="AU" term="%22Seo+MD%22">Seo MD</searchLink>; Department of Molecular Science and Technology & College of Pharmacy, Ajou University, Suwon, Korea.<br /><searchLink fieldCode="AU" term="%22Lee+H%22">Lee H</searchLink>; Korea Research Institute of Chemical Technology, Daejeon, Korea.<br /><searchLink fieldCode="AU" term="%22Lee+JY%22">Lee JY</searchLink>; Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon, Korea. leejooyong@cnu.ac.kr.<br /><searchLink fieldCode="AU" term="%22Myung+K%22">Myung K</searchLink>; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea. kmyung@ibs.re.kr.; Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea. kmyung@ibs.re.kr.
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