Astrocytic FABP5 drives non-cell-autonomous oligodendrocyte injury in multiple system atrophy by promoting TNF signaling and ferroptotic stress.

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Title: Astrocytic FABP5 drives non-cell-autonomous oligodendrocyte injury in multiple system atrophy by promoting TNF signaling and ferroptotic stress.
Authors: Wu C; School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, 518107, China. Electronic address: chengan@mail.sysu.edu.cn., Lin J; School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, 518107, China., Chen Y; Department of Industrial Engineering & Decision Analytics, Hong Kong University of Science and Technology, 999077, Hong Kong., Takahashi N; Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University Graduate School of Medicine, Hikarigaoka, Fukushima City, Fukushima, 960-1295, Japan., Chen Q; School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, 518107, China., Liu B; School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, 518107, China., Dai F; School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, 518107, China., Zhao W; School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, 518107, China., Finkelstein DI; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3010, Australia., Kawahata I; Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University Graduate School of Medicine, Hikarigaoka, Fukushima City, Fukushima, 960-1295, Japan; Department of Pharmacology, University of Shizuoka, Shizuoka, 422-8526, Japan. Electronic address: kawahata@u-shizuoka-ken.ac.jp., Fukunaga K; Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Miyagi, 980-8578, Japan. Electronic address: kfukunaga@tohoku.ac.jp., Cheng A; School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, 518107, China. Electronic address: leon.an.cheng.1q84@gmail.com.
Source: Redox biology [Redox Biol] 2026 Jun; Vol. 93, pp. 104150. Date of Electronic Publication: 2026 Apr 03.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2213-2317
DOI:10.1016/j.redox.2026.104150