An integrative single-nucleus multiomic atlas of the human left ventricle identifies gene regulatory network dynamics across cardiac development, aging, and disease.

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Title: An integrative single-nucleus multiomic atlas of the human left ventricle identifies gene regulatory network dynamics across cardiac development, aging, and disease.
Authors: Gao W; Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA. William.Gao@Pennmedicine.upenn.edu.; Penn Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA. William.Gao@Pennmedicine.upenn.edu.; Penn Institute of Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. William.Gao@Pennmedicine.upenn.edu.; Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA. William.Gao@Pennmedicine.upenn.edu.; Medical Scientist Training Program, University of Pennsylvania, Philadelphia, PA, 19104, USA. William.Gao@Pennmedicine.upenn.edu., Hu P; Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Present Address: Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai, 201306, China., Wick B; Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA, 95060, USA., Qiu Q; Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Institute of Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA., Zhang H; Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Institute of Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA., Li Y; Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Institute of Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA., Kang X; Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA., Bedi K; Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Haeussler M; Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA, 95060, USA., Sasaki K; Penn Institute of Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Biomedical Sciences, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA, 19104, USA., Margulies K; Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Wu H; Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA. haowu2@pennmedicine.upenn.edu.; Penn Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA. haowu2@pennmedicine.upenn.edu.; Penn Institute of Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. haowu2@pennmedicine.upenn.edu.; Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA. haowu2@pennmedicine.upenn.edu.
Source: Genome biology [Genome Biol] 2026 Apr 06; Vol. 27 (1). Date of Electronic Publication: 2026 Apr 06.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100960660 Publication Model: Electronic Cited Medium: Internet ISSN: 1474-760X (Electronic) Linking ISSN: 14747596 NLM ISO Abbreviation: Genome Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1474-760X
DOI:10.1186/s13059-026-04061-7