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Repurposing felodipine via hyaluronic acid-coated cetylosomes (HCCs) for parenteral active targeting of cancer: Box-Behnken statistical optimization, in vitro characterization, and in vivo studies.

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Title: Repurposing felodipine via hyaluronic acid-coated cetylosomes (HCCs) for parenteral active targeting of cancer: Box-Behnken statistical optimization, in vitro characterization, and in vivo studies.
Authors: El-Dahmy RM; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October 6 University, Cairo, Egypt. rania-moataz@o6u.edu.eg., Eltabeeb MA; Department of Industrial Pharmacy, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, Giza, Egypt., Fayez SM; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October 6 University, Cairo, Egypt., El-Emam SZ; Department of Pharmacology and Toxicology, Faculty of Pharmacy, October 6 University, Cairo, Egypt., Adl NME; Department of Pharmacology and Toxicology, Faculty of Pharmacy, October 6 University, Cairo, Egypt., Saber MM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.; Department of Clinical Pharmacy, Faculty of Pharmacy, E-JUST University, Alexandria, Egypt., Fahmy AM; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.; School of Life and Medical Sciences, University of Hertfordshire Hosted By Global Academic Foundation, New Administrative Capital, Cairo, Egypt.
Source: Drug delivery and translational research [Drug Deliv Transl Res] 2026 Apr 06. Date of Electronic Publication: 2026 Apr 06.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101540061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2190-3948 (Electronic) Linking ISSN: 2190393X NLM ISO Abbreviation: Drug Deliv Transl Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2190-3948
DOI:10.1007/s13346-026-02090-0