Discovery of Novel 2-Morpholine Tetrahydroisoquinoline CXCR4 Antagonists with Unique Properties.

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Bibliographic Details
Title: Discovery of Novel 2-Morpholine Tetrahydroisoquinoline CXCR4 Antagonists with Unique Properties.
Authors: Tahirovic YA; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Sahin Z; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Jecs E; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Miller EJ; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Nguyen HH; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Wilson RJ; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Kim M; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Fritz M; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Zaghlula Y; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Sharma SK; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Bartsch P; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Wang T; Bristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States., Sum CS; Bristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States., Cvijic ME; Bristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States., Paiva AA; Bristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States., Schroeder GM; Bristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States., Wilson LJ; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Liotta DC; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2026 Apr 23; Vol. 69 (8), pp. 9009-9050. Date of Electronic Publication: 2026 Apr 06.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.5c03471