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Discovery of Novel 2-Morpholine Tetrahydroisoquinoline CXCR4 Antagonists with Unique Properties.

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Title: Discovery of Novel 2-Morpholine Tetrahydroisoquinoline CXCR4 Antagonists with Unique Properties.
Authors: Tahirovic YA; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Sahin Z; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Jecs E; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Miller EJ; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Nguyen HH; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Wilson RJ; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Kim M; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Fritz M; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Zaghlula Y; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Sharma SK; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Bartsch P; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Wang T; Bristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States., Sum CS; Bristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States., Cvijic ME; Bristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States., Paiva AA; Bristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States., Schroeder GM; Bristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States., Wilson LJ; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States., Liotta DC; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2026 Apr 23; Vol. 69 (8), pp. 9009-9050. Date of Electronic Publication: 2026 Apr 06.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
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  Data: Discovery of Novel 2-Morpholine Tetrahydroisoquinoline CXCR4 Antagonists with Unique Properties.
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  Data: <searchLink fieldCode="AU" term="%22Tahirovic+YA%22">Tahirovic YA</searchLink>; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Sahin+Z%22">Sahin Z</searchLink>; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Jecs+E%22">Jecs E</searchLink>; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Miller+EJ%22">Miller EJ</searchLink>; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Nguyen+HH%22">Nguyen HH</searchLink>; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Wilson+RJ%22">Wilson RJ</searchLink>; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Kim+M%22">Kim M</searchLink>; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Fritz+M%22">Fritz M</searchLink>; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Zaghlula+Y%22">Zaghlula Y</searchLink>; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Sharma+SK%22">Sharma SK</searchLink>; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Bartsch+P%22">Bartsch P</searchLink>; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Wang+T%22">Wang T</searchLink>; Bristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Sum+CS%22">Sum CS</searchLink>; Bristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Cvijic+ME%22">Cvijic ME</searchLink>; Bristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Paiva+AA%22">Paiva AA</searchLink>; Bristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Schroeder+GM%22">Schroeder GM</searchLink>; Bristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Wilson+LJ%22">Wilson LJ</searchLink>; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Liotta+DC%22">Liotta DC</searchLink>; Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2026 Apr 23; Vol. 69 (8), pp. 9009-9050. <i>Date of Electronic Publication: </i>2026 Apr 06.
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        Value: 10.1021/acs.jmedchem.5c03471
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              Text: 2026 Apr 23
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