An international mega-analysis of psychedelic drug effects on brain circuit function.

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Title: An international mega-analysis of psychedelic drug effects on brain circuit function.
Authors: Girn M; Department of Neurology, University of California San Francisco, San Francisco, CA, USA. manesh.girn@ucsf.edu., Doss MK; Department of Psychiatry and Behavioral Sciences, Center for Psychedelic Research and Therapy, The University of Texas at Austin Dell Medical School, Austin, TX, USA., Roseman L; Department of Psychology, University of Exeter, Exeter, UK., Preller KH; Department of Adult Psychiatry and Psychotherapy, University of Zurich, Zurich, Switzerland., Palhano-Fontes F; Brain Institute, Universidade Federal do Rio Grande do Norte, Natal, Brazil., Pasquini L; Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Barrett FS; Center for Psychedelic and Consciousness Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Mallaroni P; Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands., Mason NL; Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands., Timmermann C; Department of Psychology, University of Exeter, Exeter, UK., McCulloch DE; Neurobiology Research Unit, Rigshospitalet, Copenhagen, Denmark., Fisher PM; Neurobiology Research Unit, Rigshospitalet, Copenhagen, Denmark., Winston BS; Center for Psychedelic and Consciousness Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Moujaes F; Department of Adult Psychiatry and Psychotherapy, University of Zurich, Zurich, Switzerland., Muller F; Department of Clinical Research, Clinical Pharmacology, University Hospital Basel, University of Basel, Basel, Switzerland., Liechti ME; Department of Clinical Research, Clinical Pharmacology, University Hospital Basel, University of Basel, Basel, Switzerland., Vollenweider FX; Department of Adult Psychiatry and Psychotherapy, University of Zurich, Zurich, Switzerland., Ramaekers JG; Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands., Kuypers K; Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands., Araujo DB; Brain Institute, Universidade Federal do Rio Grande do Norte, Natal, Brazil., Sporns O; Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA., Siegel J; Department of Psychiatry, NYU Langone Center for Psychedelic Medicine, NYU Grossman School of Medicine, New York, NY, USA., Dosenbach N; Department of Psychiatry, NYU Langone Center for Psychedelic Medicine, NYU Grossman School of Medicine, New York, NY, USA., Nutt DJ; Department of Psychology, University of Exeter, Exeter, UK., Carhart-Harris RL; Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Stamatakis EA; Division of Anaesthesia and Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Bzdok D; Department of Biomedical Engineering, The Neuro - Montreal Neurological Institute (MNI), McConnell Brain Imaging Centre (BIC), McGill University, Montreal, Quebec, Canada. danilo.bzdok@mcgill.ca.; Mila - Quebec Artificial Intelligence Institute, Montreal, Quebec, Canada. danilo.bzdok@mcgill.ca.
Source: Nature medicine [Nat Med] 2026 Apr; Vol. 32 (4), pp. 1543-1554. Date of Electronic Publication: 2026 Apr 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1546-170X
DOI:10.1038/s41591-026-04287-9