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An international mega-analysis of psychedelic drug effects on brain circuit function.

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Title: An international mega-analysis of psychedelic drug effects on brain circuit function.
Authors: Girn M; Department of Neurology, University of California San Francisco, San Francisco, CA, USA. manesh.girn@ucsf.edu., Doss MK; Department of Psychiatry and Behavioral Sciences, Center for Psychedelic Research and Therapy, The University of Texas at Austin Dell Medical School, Austin, TX, USA., Roseman L; Department of Psychology, University of Exeter, Exeter, UK., Preller KH; Department of Adult Psychiatry and Psychotherapy, University of Zurich, Zurich, Switzerland., Palhano-Fontes F; Brain Institute, Universidade Federal do Rio Grande do Norte, Natal, Brazil., Pasquini L; Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Barrett FS; Center for Psychedelic and Consciousness Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Mallaroni P; Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands., Mason NL; Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands., Timmermann C; Department of Psychology, University of Exeter, Exeter, UK., McCulloch DE; Neurobiology Research Unit, Rigshospitalet, Copenhagen, Denmark., Fisher PM; Neurobiology Research Unit, Rigshospitalet, Copenhagen, Denmark., Winston BS; Center for Psychedelic and Consciousness Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Moujaes F; Department of Adult Psychiatry and Psychotherapy, University of Zurich, Zurich, Switzerland., Muller F; Department of Clinical Research, Clinical Pharmacology, University Hospital Basel, University of Basel, Basel, Switzerland., Liechti ME; Department of Clinical Research, Clinical Pharmacology, University Hospital Basel, University of Basel, Basel, Switzerland., Vollenweider FX; Department of Adult Psychiatry and Psychotherapy, University of Zurich, Zurich, Switzerland., Ramaekers JG; Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands., Kuypers K; Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands., Araujo DB; Brain Institute, Universidade Federal do Rio Grande do Norte, Natal, Brazil., Sporns O; Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA., Siegel J; Department of Psychiatry, NYU Langone Center for Psychedelic Medicine, NYU Grossman School of Medicine, New York, NY, USA., Dosenbach N; Department of Psychiatry, NYU Langone Center for Psychedelic Medicine, NYU Grossman School of Medicine, New York, NY, USA., Nutt DJ; Department of Psychology, University of Exeter, Exeter, UK., Carhart-Harris RL; Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Stamatakis EA; Division of Anaesthesia and Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Bzdok D; Department of Biomedical Engineering, The Neuro - Montreal Neurological Institute (MNI), McConnell Brain Imaging Centre (BIC), McGill University, Montreal, Quebec, Canada. danilo.bzdok@mcgill.ca.; Mila - Quebec Artificial Intelligence Institute, Montreal, Quebec, Canada. danilo.bzdok@mcgill.ca.
Source: Nature medicine [Nat Med] 2026 Apr; Vol. 32 (4), pp. 1543-1554. Date of Electronic Publication: 2026 Apr 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Girn+M%22">Girn M</searchLink>; Department of Neurology, University of California San Francisco, San Francisco, CA, USA. manesh.girn@ucsf.edu.<br /><searchLink fieldCode="AU" term="%22Doss+MK%22">Doss MK</searchLink>; Department of Psychiatry and Behavioral Sciences, Center for Psychedelic Research and Therapy, The University of Texas at Austin Dell Medical School, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Roseman+L%22">Roseman L</searchLink>; Department of Psychology, University of Exeter, Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Preller+KH%22">Preller KH</searchLink>; Department of Adult Psychiatry and Psychotherapy, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Palhano-Fontes+F%22">Palhano-Fontes F</searchLink>; Brain Institute, Universidade Federal do Rio Grande do Norte, Natal, Brazil.<br /><searchLink fieldCode="AU" term="%22Pasquini+L%22">Pasquini L</searchLink>; Department of Neurology, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Barrett+FS%22">Barrett FS</searchLink>; Center for Psychedelic and Consciousness Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Mallaroni+P%22">Mallaroni P</searchLink>; Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Mason+NL%22">Mason NL</searchLink>; Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Timmermann+C%22">Timmermann C</searchLink>; Department of Psychology, University of Exeter, Exeter, UK.<br /><searchLink fieldCode="AU" term="%22McCulloch+DE%22">McCulloch DE</searchLink>; Neurobiology Research Unit, Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Fisher+PM%22">Fisher PM</searchLink>; Neurobiology Research Unit, Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Winston+BS%22">Winston BS</searchLink>; Center for Psychedelic and Consciousness Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Moujaes+F%22">Moujaes F</searchLink>; Department of Adult Psychiatry and Psychotherapy, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Muller+F%22">Muller F</searchLink>; Department of Clinical Research, Clinical Pharmacology, University Hospital Basel, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Liechti+ME%22">Liechti ME</searchLink>; Department of Clinical Research, Clinical Pharmacology, University Hospital Basel, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Vollenweider+FX%22">Vollenweider FX</searchLink>; Department of Adult Psychiatry and Psychotherapy, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ramaekers+JG%22">Ramaekers JG</searchLink>; Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Kuypers+K%22">Kuypers K</searchLink>; Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Araujo+DB%22">Araujo DB</searchLink>; Brain Institute, Universidade Federal do Rio Grande do Norte, Natal, Brazil.<br /><searchLink fieldCode="AU" term="%22Sporns+O%22">Sporns O</searchLink>; Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.<br /><searchLink fieldCode="AU" term="%22Siegel+J%22">Siegel J</searchLink>; Department of Psychiatry, NYU Langone Center for Psychedelic Medicine, NYU Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Dosenbach+N%22">Dosenbach N</searchLink>; Department of Psychiatry, NYU Langone Center for Psychedelic Medicine, NYU Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Nutt+DJ%22">Nutt DJ</searchLink>; Department of Psychology, University of Exeter, Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Carhart-Harris+RL%22">Carhart-Harris RL</searchLink>; Department of Neurology, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Stamatakis+EA%22">Stamatakis EA</searchLink>; Division of Anaesthesia and Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Bzdok+D%22">Bzdok D</searchLink>; Department of Biomedical Engineering, The Neuro - Montreal Neurological Institute (MNI), McConnell Brain Imaging Centre (BIC), McGill University, Montreal, Quebec, Canada. danilo.bzdok@mcgill.ca.; Mila - Quebec Artificial Intelligence Institute, Montreal, Quebec, Canada. danilo.bzdok@mcgill.ca.
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  Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2026 Apr; Vol. 32 (4), pp. 1543-1554. <i>Date of Electronic Publication: </i>2026 Apr 06.
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