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The exonic SNP rs11676272-C risk allele mediates diet-induced obesity and reduces enhancer activation.

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Title: The exonic SNP rs11676272-C risk allele mediates diet-induced obesity and reduces enhancer activation.
Authors: Wang W; School of Life Sciences, Institute of Life Science and Green Development, Hebei University, Baoding, 071002, China.; The First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, 310058, China., Li Y; School of Life Sciences, Institute of Life Science and Green Development, Hebei University, Baoding, 071002, China., Dong S; School of Life Sciences, Institute of Life Science and Green Development, Hebei University, Baoding, 071002, China., Liu Y; School of Life Sciences, Institute of Life Science and Green Development, Hebei University, Baoding, 071002, China., Guo C; School of Life Sciences, Institute of Life Science and Green Development, Hebei University, Baoding, 071002, China., Su Y; School of Life Sciences, Institute of Life Science and Green Development, Hebei University, Baoding, 071002, China., Tian W; School of Life Sciences, Institute of Life Science and Green Development, Hebei University, Baoding, 071002, China., Hu X; School of Life Sciences, Institute of Life Science and Green Development, Hebei University, Baoding, 071002, China. Xiaoyu.Hu@hbu.edu.cn.; Hebei Innovation Center for Bioengineering and Biotechnology, Hebei University, Baoding, 071002, China. Xiaoyu.Hu@hbu.edu.cn.; Hebei Basic Science Center for Biotic Interaction, Hebei University, Baoding, 071002, China. Xiaoyu.Hu@hbu.edu.cn., Wang Z; School of Life Sciences, Institute of Life Science and Green Development, Hebei University, Baoding, 071002, China. zswang@hbu.edu.cn.; Hebei Innovation Center for Bioengineering and Biotechnology, Hebei University, Baoding, 071002, China. zswang@hbu.edu.cn.; Hebei Basic Science Center for Biotic Interaction, Hebei University, Baoding, 071002, China. zswang@hbu.edu.cn.; Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Hebei University, Baoding, 071002, China. zswang@hbu.edu.cn.
Source: EMBO reports [EMBO Rep] 2026 May; Vol. 27 (9), pp. 2462-2490. Date of Electronic Publication: 2026 Apr 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The exonic SNP rs11676272-C risk allele mediates diet-induced obesity and reduces enhancer activation.
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  Data: <searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; School of Life Sciences, Institute of Life Science and Green Development, Hebei University, Baoding, 071002, China.; The First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; School of Life Sciences, Institute of Life Science and Green Development, Hebei University, Baoding, 071002, China.<br /><searchLink fieldCode="AU" term="%22Dong+S%22">Dong S</searchLink>; School of Life Sciences, Institute of Life Science and Green Development, Hebei University, Baoding, 071002, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; School of Life Sciences, Institute of Life Science and Green Development, Hebei University, Baoding, 071002, China.<br /><searchLink fieldCode="AU" term="%22Guo+C%22">Guo C</searchLink>; School of Life Sciences, Institute of Life Science and Green Development, Hebei University, Baoding, 071002, China.<br /><searchLink fieldCode="AU" term="%22Su+Y%22">Su Y</searchLink>; School of Life Sciences, Institute of Life Science and Green Development, Hebei University, Baoding, 071002, China.<br /><searchLink fieldCode="AU" term="%22Tian+W%22">Tian W</searchLink>; School of Life Sciences, Institute of Life Science and Green Development, Hebei University, Baoding, 071002, China.<br /><searchLink fieldCode="AU" term="%22Hu+X%22">Hu X</searchLink>; School of Life Sciences, Institute of Life Science and Green Development, Hebei University, Baoding, 071002, China. Xiaoyu.Hu@hbu.edu.cn.; Hebei Innovation Center for Bioengineering and Biotechnology, Hebei University, Baoding, 071002, China. Xiaoyu.Hu@hbu.edu.cn.; Hebei Basic Science Center for Biotic Interaction, Hebei University, Baoding, 071002, China. Xiaoyu.Hu@hbu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; School of Life Sciences, Institute of Life Science and Green Development, Hebei University, Baoding, 071002, China. zswang@hbu.edu.cn.; Hebei Innovation Center for Bioengineering and Biotechnology, Hebei University, Baoding, 071002, China. zswang@hbu.edu.cn.; Hebei Basic Science Center for Biotic Interaction, Hebei University, Baoding, 071002, China. zswang@hbu.edu.cn.; Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Hebei University, Baoding, 071002, China. zswang@hbu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22100963049%22">EMBO reports</searchLink> [EMBO Rep] 2026 May; Vol. 27 (9), pp. 2462-2490. <i>Date of Electronic Publication: </i>2026 Apr 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100963049 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1469-3178 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221469221X%22">1469221X </searchLink><i>NLM ISO Abbreviation: </i>EMBO Rep <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s44319-026-00758-9
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              Text: 2026 May
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