The anti-obesogenic metabolite, Lac-Phe, is elevated by metformin treatment in prostate cancer patients.

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Title: The anti-obesogenic metabolite, Lac-Phe, is elevated by metformin treatment in prostate cancer patients.
Authors: Bilusic M; Department of Medicine, Division of Medical Oncology, University of Miami Miller School of Medicine, Miami, FL, USA. mxb2305@med.miami.edu.; Sylvester Comprehensive Cancer Center, Miami, FL, USA. mxb2305@med.miami.edu., Gannamedi DP; Department of Pathology & Laboratory Medicine, University of Miami Miller School of Medicine, Miami, FL, USA., Challu B; College of Arts and Sciences, University of Miami, Coral Gables, FL, USA., Ferdous S; Department of Radiation Oncology, Division of Biology, University of Miami Miller School of Medicine, Miami, FL, USA., Mateo-Victoriano B; Department of Radiation Oncology, Division of Biology, University of Miami Miller School of Medicine, Miami, FL, USA.; Sheila and David Fuente Graduate Program in Cancer Biology, University of Miami Miller School of Medicine, Miami, FL, USA., Pokharel S; Department of Radiation Oncology, Division of Biology, University of Miami Miller School of Medicine, Miami, FL, USA., Bayik D; Sylvester Comprehensive Cancer Center, Miami, FL, USA.; Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA., Sharma J; Department of Medicine, Division of Medical Oncology, University of Miami Miller School of Medicine, Miami, FL, USA.; Sylvester Comprehensive Cancer Center, Miami, FL, USA., Lombard DB; Sylvester Comprehensive Cancer Center, Miami, FL, USA. dbl68@med.miami.edu.; Department of Pathology & Laboratory Medicine, University of Miami Miller School of Medicine, Miami, FL, USA. dbl68@med.miami.edu.; Miami VA GRECC, Miami, FL, USA. dbl68@med.miami.edu., Rai P; Sylvester Comprehensive Cancer Center, Miami, FL, USA. prai@med.miami.edu.; Department of Radiation Oncology, Division of Biology, University of Miami Miller School of Medicine, Miami, FL, USA. prai@med.miami.edu.
Source: EMBO molecular medicine [EMBO Mol Med] 2026 May; Vol. 18 (5), pp. 1551-1562. Date of Electronic Publication: 2026 Apr 06.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1757-4684
DOI:10.1038/s44321-026-00408-6