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The anti-obesogenic metabolite, Lac-Phe, is elevated by metformin treatment in prostate cancer patients.

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Title: The anti-obesogenic metabolite, Lac-Phe, is elevated by metformin treatment in prostate cancer patients.
Authors: Bilusic M; Department of Medicine, Division of Medical Oncology, University of Miami Miller School of Medicine, Miami, FL, USA. mxb2305@med.miami.edu.; Sylvester Comprehensive Cancer Center, Miami, FL, USA. mxb2305@med.miami.edu., Gannamedi DP; Department of Pathology & Laboratory Medicine, University of Miami Miller School of Medicine, Miami, FL, USA., Challu B; College of Arts and Sciences, University of Miami, Coral Gables, FL, USA., Ferdous S; Department of Radiation Oncology, Division of Biology, University of Miami Miller School of Medicine, Miami, FL, USA., Mateo-Victoriano B; Department of Radiation Oncology, Division of Biology, University of Miami Miller School of Medicine, Miami, FL, USA.; Sheila and David Fuente Graduate Program in Cancer Biology, University of Miami Miller School of Medicine, Miami, FL, USA., Pokharel S; Department of Radiation Oncology, Division of Biology, University of Miami Miller School of Medicine, Miami, FL, USA., Bayik D; Sylvester Comprehensive Cancer Center, Miami, FL, USA.; Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA., Sharma J; Department of Medicine, Division of Medical Oncology, University of Miami Miller School of Medicine, Miami, FL, USA.; Sylvester Comprehensive Cancer Center, Miami, FL, USA., Lombard DB; Sylvester Comprehensive Cancer Center, Miami, FL, USA. dbl68@med.miami.edu.; Department of Pathology & Laboratory Medicine, University of Miami Miller School of Medicine, Miami, FL, USA. dbl68@med.miami.edu.; Miami VA GRECC, Miami, FL, USA. dbl68@med.miami.edu., Rai P; Sylvester Comprehensive Cancer Center, Miami, FL, USA. prai@med.miami.edu.; Department of Radiation Oncology, Division of Biology, University of Miami Miller School of Medicine, Miami, FL, USA. prai@med.miami.edu.
Source: EMBO molecular medicine [EMBO Mol Med] 2026 May; Vol. 18 (5), pp. 1551-1562. Date of Electronic Publication: 2026 Apr 06.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The anti-obesogenic metabolite, Lac-Phe, is elevated by metformin treatment in prostate cancer patients.
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  Data: <searchLink fieldCode="AU" term="%22Bilusic+M%22">Bilusic M</searchLink>; Department of Medicine, Division of Medical Oncology, University of Miami Miller School of Medicine, Miami, FL, USA. mxb2305@med.miami.edu.; Sylvester Comprehensive Cancer Center, Miami, FL, USA. mxb2305@med.miami.edu.<br /><searchLink fieldCode="AU" term="%22Gannamedi+DP%22">Gannamedi DP</searchLink>; Department of Pathology & Laboratory Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Challu+B%22">Challu B</searchLink>; College of Arts and Sciences, University of Miami, Coral Gables, FL, USA.<br /><searchLink fieldCode="AU" term="%22Ferdous+S%22">Ferdous S</searchLink>; Department of Radiation Oncology, Division of Biology, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Mateo-Victoriano+B%22">Mateo-Victoriano B</searchLink>; Department of Radiation Oncology, Division of Biology, University of Miami Miller School of Medicine, Miami, FL, USA.; Sheila and David Fuente Graduate Program in Cancer Biology, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Pokharel+S%22">Pokharel S</searchLink>; Department of Radiation Oncology, Division of Biology, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Bayik+D%22">Bayik D</searchLink>; Sylvester Comprehensive Cancer Center, Miami, FL, USA.; Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Sharma+J%22">Sharma J</searchLink>; Department of Medicine, Division of Medical Oncology, University of Miami Miller School of Medicine, Miami, FL, USA.; Sylvester Comprehensive Cancer Center, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Lombard+DB%22">Lombard DB</searchLink>; Sylvester Comprehensive Cancer Center, Miami, FL, USA. dbl68@med.miami.edu.; Department of Pathology & Laboratory Medicine, University of Miami Miller School of Medicine, Miami, FL, USA. dbl68@med.miami.edu.; Miami VA GRECC, Miami, FL, USA. dbl68@med.miami.edu.<br /><searchLink fieldCode="AU" term="%22Rai+P%22">Rai P</searchLink>; Sylvester Comprehensive Cancer Center, Miami, FL, USA. prai@med.miami.edu.; Department of Radiation Oncology, Division of Biology, University of Miami Miller School of Medicine, Miami, FL, USA. prai@med.miami.edu.
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  Data: <searchLink fieldCode="JN" term="%22101487380%22">EMBO molecular medicine</searchLink> [EMBO Mol Med] 2026 May; Vol. 18 (5), pp. 1551-1562. <i>Date of Electronic Publication: </i>2026 Apr 06.
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              Text: 2026 May
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