Hyperglycemia impairs cognitive function by inducing mitochondrial damage through lactylation of LRPPRC at K223.
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| Title: | Hyperglycemia impairs cognitive function by inducing mitochondrial damage through lactylation of LRPPRC at K223. |
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| Authors: | Xu J; Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541199, P. R. China.; Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin, Guangxi, 541199, P. R. China., Hao Y; Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541199, P. R. China.; Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin, Guangxi, 541199, P. R. China., Cao J; Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541199, P. R. China.; Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin, Guangxi, 541199, P. R. China., Yang X; Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541199, P. R. China.; Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin, Guangxi, 541199, P. R. China., Gao Y; Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, P. R. China., Sun X; Department of Endocrinology and Metabolism, Affiliated Hospital of Shandong Second Medical University, Weifang, 261031, P. R. China., Nie R; The Department of Integrated Traditional Chinese and Western Medicine, The First Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541001, P. R. China., Zhong Q; Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541199, P. R. China.; Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin, Guangxi, 541199, P. R. China., Zhong Y; Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541199, P. R. China.; Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin, Guangxi, 541199, P. R. China., Zhong J; The Second Clinical College of Guilin Medical University, Guilin, Guangxi, 541199, P. R. China., Zheng T; Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541199, P. R. China. ZhengTP@glmc.edu.cn.; Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin, Guangxi, 541199, P. R. China. ZhengTP@glmc.edu.cn.; Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin, Guangxi, 541199, P. R. China. ZhengTP@glmc.edu.cn. |
| Source: | EMBO molecular medicine [EMBO Mol Med] 2026 Jun; Vol. 18 (6), pp. 2038-2061. Date of Electronic Publication: 2026 Apr 06. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1757-4684 |
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| DOI: | 10.1038/s44321-026-00422-8 |
