Impact of zervimesine on the neuroinflammatory biomarker GFAP and related proteomic molecular correlates in plasma of participants from a phase 2 clinical trial in Alzheimer's disease.

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Title: Impact of zervimesine on the neuroinflammatory biomarker GFAP and related proteomic molecular correlates in plasma of participants from a phase 2 clinical trial in Alzheimer's disease.
Authors: Di Caro V; Cognition Therapeutics, 2403 Sidney Street Suite 261, Pittsburgh, 15203, PA, USA., Cho E; Cognition Therapeutics, 2403 Sidney Street Suite 261, Pittsburgh, 15203, PA, USA., Thiel J; Cognition Therapeutics, 2403 Sidney Street Suite 261, Pittsburgh, 15203, PA, USA., Lizama BN; Cognition Therapeutics, 2403 Sidney Street Suite 261, Pittsburgh, 15203, PA, USA., Koel-Simmelink MJA; Department of Laboratory Medicine, VU University Medical Center, De Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands., Pandey K; Emtherapro Inc, Systems Biology, 1374 Pasadena Avenue NE, Atlanta, GA, 30306, USA., Duong D; Emory University School of Medicine, Biochemistry, 1510 Clifton Road, 4001 Rollins Research Center, Atlanta, GA, 30322, USA., Seyfried NT; Emory University School of Medicine, Biochemistry, 1510 Clifton Road, 4001 Rollins Research Center, Atlanta, GA, 30322, USA., Grundman M; Global R&D Partners, LLC, 13236 Haxton Place, San Diego, CA, 92130, USA.; Department of Neurosciences, University of California, 9375 Gilman Dr, San Diego, CA, 92161, USA., Teunissen CE; Department of Laboratory Medicine, VU University Medical Center, De Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands., Zetterberg H; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.; UK Dementia Research Institute at UCL, London, UK.; Hong Kong Center for Neurodegenerative Diseases, InnoHK, Hong Kong, China.; Centre for Brain Research, Indian Institute of Science, Bangalore, India., Blennow K; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden., Caggiano AO; Cognition Therapeutics, 2403 Sidney Street Suite 261, Pittsburgh, 15203, PA, USA., Hamby ME; Cognition Therapeutics, 2403 Sidney Street Suite 261, Pittsburgh, 15203, PA, USA. mhamby@cogrx.com.
Source: Alzheimer's research & therapy [Alzheimers Res Ther] 2026 Apr 06; Vol. 18 (1). Date of Electronic Publication: 2026 Apr 06.
Publication Type: Journal Article; Clinical Trial, Phase II; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN: 1758-9193 (Electronic) NLM ISO Abbreviation: Alzheimers Res Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1758-9193
DOI:10.1186/s13195-026-02025-4