Impact of zervimesine on the neuroinflammatory biomarker GFAP and related proteomic molecular correlates in plasma of participants from a phase 2 clinical trial in Alzheimer's disease.
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| Title: | Impact of zervimesine on the neuroinflammatory biomarker GFAP and related proteomic molecular correlates in plasma of participants from a phase 2 clinical trial in Alzheimer's disease. |
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| Authors: | Di Caro V; Cognition Therapeutics, 2403 Sidney Street Suite 261, Pittsburgh, 15203, PA, USA., Cho E; Cognition Therapeutics, 2403 Sidney Street Suite 261, Pittsburgh, 15203, PA, USA., Thiel J; Cognition Therapeutics, 2403 Sidney Street Suite 261, Pittsburgh, 15203, PA, USA., Lizama BN; Cognition Therapeutics, 2403 Sidney Street Suite 261, Pittsburgh, 15203, PA, USA., Koel-Simmelink MJA; Department of Laboratory Medicine, VU University Medical Center, De Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands., Pandey K; Emtherapro Inc, Systems Biology, 1374 Pasadena Avenue NE, Atlanta, GA, 30306, USA., Duong D; Emory University School of Medicine, Biochemistry, 1510 Clifton Road, 4001 Rollins Research Center, Atlanta, GA, 30322, USA., Seyfried NT; Emory University School of Medicine, Biochemistry, 1510 Clifton Road, 4001 Rollins Research Center, Atlanta, GA, 30322, USA., Grundman M; Global R&D Partners, LLC, 13236 Haxton Place, San Diego, CA, 92130, USA.; Department of Neurosciences, University of California, 9375 Gilman Dr, San Diego, CA, 92161, USA., Teunissen CE; Department of Laboratory Medicine, VU University Medical Center, De Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands., Zetterberg H; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.; UK Dementia Research Institute at UCL, London, UK.; Hong Kong Center for Neurodegenerative Diseases, InnoHK, Hong Kong, China.; Centre for Brain Research, Indian Institute of Science, Bangalore, India., Blennow K; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden., Caggiano AO; Cognition Therapeutics, 2403 Sidney Street Suite 261, Pittsburgh, 15203, PA, USA., Hamby ME; Cognition Therapeutics, 2403 Sidney Street Suite 261, Pittsburgh, 15203, PA, USA. mhamby@cogrx.com. |
| Source: | Alzheimer's research & therapy [Alzheimers Res Ther] 2026 Apr 06; Vol. 18 (1). Date of Electronic Publication: 2026 Apr 06. |
| Publication Type: | Journal Article; Clinical Trial, Phase II; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN: 1758-9193 (Electronic) NLM ISO Abbreviation: Alzheimers Res Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41943055 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Impact of zervimesine on the neuroinflammatory biomarker GFAP and related proteomic molecular correlates in plasma of participants from a phase 2 clinical trial in Alzheimer's disease. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Di+Caro+V%22">Di Caro V</searchLink>; Cognition Therapeutics, 2403 Sidney Street Suite 261, Pittsburgh, 15203, PA, USA.<br /><searchLink fieldCode="AU" term="%22Cho+E%22">Cho E</searchLink>; Cognition Therapeutics, 2403 Sidney Street Suite 261, Pittsburgh, 15203, PA, USA.<br /><searchLink fieldCode="AU" term="%22Thiel+J%22">Thiel J</searchLink>; Cognition Therapeutics, 2403 Sidney Street Suite 261, Pittsburgh, 15203, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lizama+BN%22">Lizama BN</searchLink>; Cognition Therapeutics, 2403 Sidney Street Suite 261, Pittsburgh, 15203, PA, USA.<br /><searchLink fieldCode="AU" term="%22Koel-Simmelink+MJA%22">Koel-Simmelink MJA</searchLink>; Department of Laboratory Medicine, VU University Medical Center, De Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Pandey+K%22">Pandey K</searchLink>; Emtherapro Inc, Systems Biology, 1374 Pasadena Avenue NE, Atlanta, GA, 30306, USA.<br /><searchLink fieldCode="AU" term="%22Duong+D%22">Duong D</searchLink>; Emory University School of Medicine, Biochemistry, 1510 Clifton Road, 4001 Rollins Research Center, Atlanta, GA, 30322, USA.<br /><searchLink fieldCode="AU" term="%22Seyfried+NT%22">Seyfried NT</searchLink>; Emory University School of Medicine, Biochemistry, 1510 Clifton Road, 4001 Rollins Research Center, Atlanta, GA, 30322, USA.<br /><searchLink fieldCode="AU" term="%22Grundman+M%22">Grundman M</searchLink>; Global R&D Partners, LLC, 13236 Haxton Place, San Diego, CA, 92130, USA.; Department of Neurosciences, University of California, 9375 Gilman Dr, San Diego, CA, 92161, USA.<br /><searchLink fieldCode="AU" term="%22Teunissen+CE%22">Teunissen CE</searchLink>; Department of Laboratory Medicine, VU University Medical Center, De Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Zetterberg+H%22">Zetterberg H</searchLink>; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.; UK Dementia Research Institute at UCL, London, UK.; Hong Kong Center for Neurodegenerative Diseases, InnoHK, Hong Kong, China.; Centre for Brain Research, Indian Institute of Science, Bangalore, India.<br /><searchLink fieldCode="AU" term="%22Blennow+K%22">Blennow K</searchLink>; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Caggiano+AO%22">Caggiano AO</searchLink>; Cognition Therapeutics, 2403 Sidney Street Suite 261, Pittsburgh, 15203, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hamby+ME%22">Hamby ME</searchLink>; Cognition Therapeutics, 2403 Sidney Street Suite 261, Pittsburgh, 15203, PA, USA. mhamby@cogrx.com. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101511643%22">Alzheimer's research & therapy</searchLink> [Alzheimers Res Ther] 2026 Apr 06; Vol. 18 (1). <i>Date of Electronic Publication: </i>2026 Apr 06. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Clinical Trial, Phase II; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central+Ltd%22">BioMed Central Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101511643 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1758-9193 (Electronic) <i>NLM ISO Abbreviation: </i>Alzheimers Res Ther <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41943055 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s13195-026-02025-4 Languages: – Code: eng Text: English Titles: – TitleFull: Impact of zervimesine on the neuroinflammatory biomarker GFAP and related proteomic molecular correlates in plasma of participants from a phase 2 clinical trial in Alzheimer's disease. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Di Caro V – PersonEntity: Name: NameFull: Cho E – PersonEntity: Name: NameFull: Thiel J – PersonEntity: Name: NameFull: Lizama BN – PersonEntity: Name: NameFull: Koel-Simmelink MJA – PersonEntity: Name: NameFull: Pandey K – PersonEntity: Name: NameFull: Duong D – PersonEntity: Name: NameFull: Seyfried NT – PersonEntity: Name: NameFull: Grundman M – PersonEntity: Name: NameFull: Teunissen CE – PersonEntity: Name: NameFull: Zetterberg H – PersonEntity: Name: NameFull: Blennow K – PersonEntity: Name: NameFull: Caggiano AO – PersonEntity: Name: NameFull: Hamby ME IsPartOfRelationships: – BibEntity: Dates: – D: 06 M: 04 Text: 2026 Apr 06 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1758-9193 Numbering: – Type: volume Value: 18 – Type: issue Value: 1 Titles: – TitleFull: Alzheimer's research & therapy Type: main |
| ResultId | 1 |
