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Systemic Inflammation Modulates Clearance and Drives Extra-Hepatic Distribution of Extracellular Vesicles.

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Title: Systemic Inflammation Modulates Clearance and Drives Extra-Hepatic Distribution of Extracellular Vesicles.
Authors: Pavlova S; Division of Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, ANA Futura, Alfred-Nobels-Allé 8, Huddinge, Stockholm, Sweden.; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska University Hospital, Huddinge, Stockholm, Sweden.; Karolinska ATMP Center, Karolinska Institutet, ANA Futura, Alfred-Nobels-Allé 8, Huddinge, Stockholm, Sweden., Mamand DR; Division of Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, ANA Futura, Alfred-Nobels-Allé 8, Huddinge, Stockholm, Sweden.; Karolinska ATMP Center, Karolinska Institutet, ANA Futura, Alfred-Nobels-Allé 8, Huddinge, Stockholm, Sweden.; Breast Center, Karolinska Comprehensive Cancer Center, Karolinska University Hospital, Solna, Stockholm, Sweden.; Biology Research Center, Research Center, University of Zakho, Zakho, Duhok, Kurdistan Region, Iraq., Görgens A; Division of Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, ANA Futura, Alfred-Nobels-Allé 8, Huddinge, Stockholm, Sweden.; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska University Hospital, Huddinge, Stockholm, Sweden.; Karolinska ATMP Center, Karolinska Institutet, ANA Futura, Alfred-Nobels-Allé 8, Huddinge, Stockholm, Sweden., Zickler AM; Division of Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, ANA Futura, Alfred-Nobels-Allé 8, Huddinge, Stockholm, Sweden.; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska University Hospital, Huddinge, Stockholm, Sweden.; Karolinska ATMP Center, Karolinska Institutet, ANA Futura, Alfred-Nobels-Allé 8, Huddinge, Stockholm, Sweden., Zheng W; Division of Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, ANA Futura, Alfred-Nobels-Allé 8, Huddinge, Stockholm, Sweden.; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska University Hospital, Huddinge, Stockholm, Sweden.; Karolinska ATMP Center, Karolinska Institutet, ANA Futura, Alfred-Nobels-Allé 8, Huddinge, Stockholm, Sweden., Liang X; Division of Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, ANA Futura, Alfred-Nobels-Allé 8, Huddinge, Stockholm, Sweden.; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska University Hospital, Huddinge, Stockholm, Sweden.; Karolinska ATMP Center, Karolinska Institutet, ANA Futura, Alfred-Nobels-Allé 8, Huddinge, Stockholm, Sweden., Wiklander OPB; Division of Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, ANA Futura, Alfred-Nobels-Allé 8, Huddinge, Stockholm, Sweden.; Karolinska ATMP Center, Karolinska Institutet, ANA Futura, Alfred-Nobels-Allé 8, Huddinge, Stockholm, Sweden.; Breast Center, Karolinska Comprehensive Cancer Center, Karolinska University Hospital, Solna, Stockholm, Sweden., Abedi-Valugerdi M; Division of Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, ANA Futura, Alfred-Nobels-Allé 8, Huddinge, Stockholm, Sweden., Van Wonterghem E; Barriers in Inflammation Lab, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; VIB-UGent Center for Inflammation Research, VIB, Ghent, Belgium., Xie J; Barriers in Inflammation Lab, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; VIB-UGent Center for Inflammation Research, VIB, Ghent, Belgium., Niu Z; Division of Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, ANA Futura, Alfred-Nobels-Allé 8, Huddinge, Stockholm, Sweden.; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska University Hospital, Huddinge, Stockholm, Sweden., Roudi S; Division of Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, ANA Futura, Alfred-Nobels-Allé 8, Huddinge, Stockholm, Sweden.; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska University Hospital, Huddinge, Stockholm, Sweden.; Karolinska ATMP Center, Karolinska Institutet, ANA Futura, Alfred-Nobels-Allé 8, Huddinge, Stockholm, Sweden., Yan D; Institute of Developmental and Regenerative Medicine, Department of Paediatrics, University of Oxford, Headington, Oxford, UK.; Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK., Makkar R; Institute of Developmental and Regenerative Medicine, Department of Paediatrics, University of Oxford, Headington, Oxford, UK., Zhou G; Division of Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, ANA Futura, Alfred-Nobels-Allé 8, Huddinge, Stockholm, Sweden.; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska University Hospital, Huddinge, Stockholm, Sweden., Imami K; RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan., Wood MJA; Institute of Developmental and Regenerative Medicine, Department of Paediatrics, University of Oxford, Headington, Oxford, UK.; Department of Paediatrics, University of Oxford, Roosevelt Dr, Headington, Oxford, UK.; MRC Centre of Research Excellence, Oxford, UK.; Oxford Harrington Rare Disease Centre, Oxford, UK., Vandenbroucke RE; Barriers in Inflammation Lab, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; VIB-UGent Center for Inflammation Research, VIB, Ghent, Belgium., Gupta D; Division of Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, ANA Futura, Alfred-Nobels-Allé 8, Huddinge, Stockholm, Sweden.; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska University Hospital, Huddinge, Stockholm, Sweden.; Institute of Developmental and Regenerative Medicine, Department of Paediatrics, University of Oxford, Headington, Oxford, UK.; Department of Paediatrics, University of Oxford, Roosevelt Dr, Headington, Oxford, UK.; MRC Centre of Research Excellence, Oxford, UK., Andaloussi SE; Division of Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, ANA Futura, Alfred-Nobels-Allé 8, Huddinge, Stockholm, Sweden.; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska University Hospital, Huddinge, Stockholm, Sweden.; Karolinska ATMP Center, Karolinska Institutet, ANA Futura, Alfred-Nobels-Allé 8, Huddinge, Stockholm, Sweden.
Source: Journal of extracellular vesicles [J Extracell Vesicles] 2026 Apr; Vol. 15 (4), pp. e70256.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 101610479 Publication Model: Print Cited Medium: Internet ISSN: 2001-3078 (Electronic) Linking ISSN: 20013078 NLM ISO Abbreviation: J Extracell Vesicles Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2001-3078
DOI:10.1002/jev2.70256