Single-oocyte full-length isoform sequencing unveils the impact of transposable elements on RNA diversity and stability.
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| Title: | Single-oocyte full-length isoform sequencing unveils the impact of transposable elements on RNA diversity and stability. |
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| Authors: | Wang Y; State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.; National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China.; Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China.; Beijing Key Laboratory of Collaborative Innovation in Frontier Technologies for Population Quality, Beijing, China., Wang W; State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.; National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China.; Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China.; Beijing Key Laboratory of Collaborative Innovation in Frontier Technologies for Population Quality, Beijing, China.; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.; Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China., Liu Y; State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.; National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China.; Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China.; Beijing Key Laboratory of Collaborative Innovation in Frontier Technologies for Population Quality, Beijing, China., He Y; State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.; National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China.; Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China.; Beijing Key Laboratory of Collaborative Innovation in Frontier Technologies for Population Quality, Beijing, China.; Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China., Song H; State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.; National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China.; Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China.; Beijing Key Laboratory of Collaborative Innovation in Frontier Technologies for Population Quality, Beijing, China., Yang M; State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.; National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China.; Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China.; Beijing Key Laboratory of Collaborative Innovation in Frontier Technologies for Population Quality, Beijing, China., Wang N; State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.; National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China.; Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China.; Beijing Key Laboratory of Collaborative Innovation in Frontier Technologies for Population Quality, Beijing, China., Wang X; State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.; National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China.; Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China.; Beijing Key Laboratory of Collaborative Innovation in Frontier Technologies for Population Quality, Beijing, China., Ding L; State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.; National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China.; Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China.; Beijing Key Laboratory of Collaborative Innovation in Frontier Technologies for Population Quality, Beijing, China., Kuo Y; State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.; National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China.; Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China.; Beijing Key Laboratory of Collaborative Innovation in Frontier Technologies for Population Quality, Beijing, China., Xiu Y; State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.; National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China.; Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China.; Beijing Key Laboratory of Collaborative Innovation in Frontier Technologies for Population Quality, Beijing, China.; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.; Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China., Du Z; State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.; National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China.; Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China.; Beijing Key Laboratory of Collaborative Innovation in Frontier Technologies for Population Quality, Beijing, China., Chen L; State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.; National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China.; Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China.; Beijing Key Laboratory of Collaborative Innovation in Frontier Technologies for Population Quality, Beijing, China., Lian Y; State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.; National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China.; Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China.; Beijing Key Laboratory of Collaborative Innovation in Frontier Technologies for Population Quality, Beijing, China., Liu Q; State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China. liuqiangtaian2008@163.com.; National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China. liuqiangtaian2008@163.com.; Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China. liuqiangtaian2008@163.com.; Beijing Key Laboratory of Collaborative Innovation in Frontier Technologies for Population Quality, Beijing, China. liuqiangtaian2008@163.com., Yan L; State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China. yanliyingkind@aliyun.com.; National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China. yanliyingkind@aliyun.com.; Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China. yanliyingkind@aliyun.com.; Beijing Key Laboratory of Collaborative Innovation in Frontier Technologies for Population Quality, Beijing, China. yanliyingkind@aliyun.com.; Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Chinese Academy of Medical Sciences, Beijing, China. yanliyingkind@aliyun.com., Qiao J; State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China. jie.qiao@263.net.; National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China. jie.qiao@263.net.; Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China. jie.qiao@263.net.; Beijing Key Laboratory of Collaborative Innovation in Frontier Technologies for Population Quality, Beijing, China. jie.qiao@263.net.; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China. jie.qiao@263.net.; Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China. jie.qiao@263.net.; Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Chinese Academy of Medical Sciences, Beijing, China. jie.qiao@263.net.; Beijing Advanced Innovation Center for Genomics, Beijing, China. jie.qiao@263.net., Yuan P; State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China. peng.yuan@bjmu.edu.cn.; National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China. peng.yuan@bjmu.edu.cn.; Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China. peng.yuan@bjmu.edu.cn.; Beijing Key Laboratory of Collaborative Innovation in Frontier Technologies for Population Quality, Beijing, China. peng.yuan@bjmu.edu.cn.; Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Chinese Academy of Medical Sciences, Beijing, China. peng.yuan@bjmu.edu.cn. |
| Source: | Nature communications [Nat Commun] 2026 Apr 07; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 07. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-026-71425-9 |
