Development and validation of an activatable PET radiotracer reporting extracellular myeloperoxidase activity for the detection of unstable atherosclerotic plaque.

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Title: Development and validation of an activatable PET radiotracer reporting extracellular myeloperoxidase activity for the detection of unstable atherosclerotic plaque.
Authors: Keeling GP; School of Biomedical Engineering and Imaging Sciences, Res. Dept. of Cardiovascular Imaging, King's College London, London, UK., Wang X; School of Biomedical Engineering and Imaging Sciences, Res. Dept. of Cardiovascular Imaging, King's College London, London, UK., Chen W; Heart Research Institute, Newtown, NSW, Australia.; Faculty of Medicine and Health, The University of Sydney, NSW, 2006, Sydney, Australia.; Guangdong Key Laboratory of Vascular Diseases, Guangzhou Institute of Cardiovascular Disease, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China., Chaher N; School of Biomedical Engineering and Imaging Sciences, Res. Dept. of Cardiovascular Imaging, King's College London, London, UK., Gao L; School of Biomedical Engineering and Imaging Sciences, Res. Dept. of Cardiovascular Imaging, King's College London, London, UK., Andia ME; School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Tumanov S; Heart Research Institute, Newtown, NSW, Australia.; Faculty of Medicine and Health, The University of Sydney, NSW, 2006, Sydney, Australia., Golda P; London Metallomics Facility, King's College London, London, UK., Chowdhury MM; Department of Vascular Surgery, University of Cambridge, Cambridge, UK., Saha P; School of Biomedical Engineering and Imaging Sciences, Res. Dept. of Cardiovascular Imaging, King's College London, London, UK., Livieratos L; School of Biomedical Engineering and Imaging Sciences, Res. Dept. of Cardiovascular Imaging, King's College London, London, UK.; Nuclear Medicine Department, Guy's & St Thomas' Hospitals NHS Foundation Trust, London, UK., Nadel J; Heart Research Institute, Newtown, NSW, Australia.; St Vincent's Hospital, Sydney, NSW, Australia., Stocker R; Heart Research Institute, Newtown, NSW, Australia. roland.stocker@hri.org.au., Phinikaridou A; School of Biomedical Engineering and Imaging Sciences, Res. Dept. of Cardiovascular Imaging, King's College London, London, UK. alkystis.1.phinikaridou@kcl.ac.uk.; King's BHF Centre of Research Excellence, London, UK. alkystis.1.phinikaridou@kcl.ac.uk.
Source: Npj imaging [Npj Imaging] 2026 Apr 07; Vol. 4 (1). Date of Electronic Publication: 2026 Apr 07.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: Switzerland NLM ID: 9918733285306676 Publication Model: Electronic Cited Medium: Internet ISSN: 2948-197X (Electronic) Linking ISSN: 2948197X NLM ISO Abbreviation: Npj Imaging Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:2948-197X
DOI:10.1038/s44303-026-00156-9