Broadly neutralizing nanobodies target a defined structural pivot site on the RSV fusion protein.

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Title: Broadly neutralizing nanobodies target a defined structural pivot site on the RSV fusion protein.
Authors: Wang Q; Department of Infectious Disease, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China.; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230026, China.; Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases, Hefei, Anhui, 230026, China., Ke X; CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China., Li E; Department of Infectious Disease, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China.; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230026, China.; Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases, Hefei, Anhui, 230026, China., Hong D; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230026, China.; Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases, Hefei, Anhui, 230026, China., Cheng Z; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230026, China.; Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases, Hefei, Anhui, 230026, China., Li H; CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China., Zhang J; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230026, China.; Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases, Hefei, Anhui, 230026, China., Jin T; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230026, China.; Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases, Hefei, Anhui, 230026, China., Gong R; CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China., Shu B; CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China. shubo@wh.iov.cn., Chiu S; Department of Infectious Disease, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China. qiux@ustc.edu.cn.; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230026, China. qiux@ustc.edu.cn.; Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases, Hefei, Anhui, 230026, China. qiux@ustc.edu.cn.
Source: EMBO molecular medicine [EMBO Mol Med] 2026 May; Vol. 18 (5), pp. 1866-1883. Date of Electronic Publication: 2026 Apr 07.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1757-4684
DOI:10.1038/s44321-026-00412-w