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Novel Pyrazole-3-Cyano-2-Pyridinone Hybrids as Multitarget Anti-Inflammatory Agents: Synthesis, Computational Modeling, and Biological Evaluation.

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Title: Novel Pyrazole-3-Cyano-2-Pyridinone Hybrids as Multitarget Anti-Inflammatory Agents: Synthesis, Computational Modeling, and Biological Evaluation.
Authors: Hussein BRM; Department of Chemistry, Faculty of Science, Sohag University, Sohag, 82524, Egypt., Salem IM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sphinx University, New Assuit City, Assiut, 71515, Egypt., Aziz HA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, New Valley University, New Valley, 72511, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, New Valley National University, New Valley, 72511, Egypt., Alshazly O; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, 82524, Sohag, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag National University, Sohag, 82524, Egypt., Hofny HA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, 82524, Sohag, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag National University, Sohag, 82524, Egypt., Mohassab AM; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt.; Medicinal Chemistry Department, Faculty of Pharmacy, Minia National University, New Minia, Egypt., Awan ZA; Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia., Ibrahim TS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, 21589, Saudi Arabia., Mahmoud EM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt.; Course of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, Gifu, 501-1193, Japan., Bräse S; Institute for Biological and Chemical System, Karlsruhe Institute of Technology, Karlsruhe, 76131, Germany., Mohamed MFA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, New Valley University, New Valley, 72511, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, New Valley National University, New Valley, 72511, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, 82524, Sohag, Egypt.
Source: Drug design, development and therapy [Drug Des Devel Ther] 2026 Apr 01; Vol. 20, pp. 570813. Date of Electronic Publication: 2026 Apr 01 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN: 1177-8881 (Electronic) Linking ISSN: 11778881 NLM ISO Abbreviation: Drug Des Devel Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Hussein+BRM%22">Hussein BRM</searchLink>; Department of Chemistry, Faculty of Science, Sohag University, Sohag, 82524, Egypt.<br /><searchLink fieldCode="AU" term="%22Salem+IM%22">Salem IM</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sphinx University, New Assuit City, Assiut, 71515, Egypt.<br /><searchLink fieldCode="AU" term="%22Aziz+HA%22">Aziz HA</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, New Valley University, New Valley, 72511, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, New Valley National University, New Valley, 72511, Egypt.<br /><searchLink fieldCode="AU" term="%22Alshazly+O%22">Alshazly O</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, 82524, Sohag, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag National University, Sohag, 82524, Egypt.<br /><searchLink fieldCode="AU" term="%22Hofny+HA%22">Hofny HA</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, 82524, Sohag, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag National University, Sohag, 82524, Egypt.<br /><searchLink fieldCode="AU" term="%22Mohassab+AM%22">Mohassab AM</searchLink>; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt.; Medicinal Chemistry Department, Faculty of Pharmacy, Minia National University, New Minia, Egypt.<br /><searchLink fieldCode="AU" term="%22Awan+ZA%22">Awan ZA</searchLink>; Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Ibrahim+TS%22">Ibrahim TS</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Mahmoud+EM%22">Mahmoud EM</searchLink>; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt.; Course of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, Gifu, 501-1193, Japan.<br /><searchLink fieldCode="AU" term="%22Bräse+S%22">Bräse S</searchLink>; Institute for Biological and Chemical System, Karlsruhe Institute of Technology, Karlsruhe, 76131, Germany.<br /><searchLink fieldCode="AU" term="%22Mohamed+MFA%22">Mohamed MFA</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, New Valley University, New Valley, 72511, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, New Valley National University, New Valley, 72511, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, 82524, Sohag, Egypt.
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  Data: <searchLink fieldCode="JN" term="%22101475745%22">Drug design, development and therapy</searchLink> [Drug Des Devel Ther] 2026 Apr 01; Vol. 20, pp. 570813. <i>Date of Electronic Publication: </i>2026 Apr 01 (<i>Print Publication: </i>2026).
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              Text: 2026 Apr 01
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