Multiomics and multi-region spatial transcriptome analysis reveal cellular networks and pathways associated with HCC recurrence.

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Title: Multiomics and multi-region spatial transcriptome analysis reveal cellular networks and pathways associated with HCC recurrence.
Authors: Seshachalam VP; Program in Translational and Clinical Liver Research, National Cancer Center Singapore, Republic of Singapore., Sari IN; Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Toh K; Program in Translational and Clinical Liver Research, National Cancer Center Singapore, Republic of Singapore., Majee P; Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Chong SL; Program in Translational and Clinical Liver Research, National Cancer Center Singapore, Republic of Singapore., Sekar K; Program in Translational and Clinical Liver Research, National Cancer Center Singapore, Republic of Singapore., Aiderus A; Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Idzham K; Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Qi OY; Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Chong LY; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore., Caldez M; Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Shanmugam R; Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Ying DHH; Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Lee E; Bioprocessing Technology Institute (BTI), Agency of Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore., Toh J; Bioprocessing Technology Institute (BTI), Agency of Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore., Lele W; Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Lee JYJ; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore., Zhong G; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore., Chew SC; Program in Translational and Clinical Liver Research, National Cancer Center Singapore, Republic of Singapore., Chen GB; Program in Translational and Clinical Liver Research, National Cancer Center Singapore, Republic of Singapore., Wu L; Program in Translational and Clinical Liver Research, National Cancer Center Singapore, Republic of Singapore., Chung AYF; Department of Hepatopancreatobiliary and Transplant Surgery, National Cancer Centre Singapore and Singapore General Hospital, Republic of Singapore., Cheow PC; Department of Hepatopancreatobiliary and Transplant Surgery, National Cancer Centre Singapore and Singapore General Hospital, Republic of Singapore., Kam JH; Department of Hepatopancreatobiliary and Transplant Surgery, National Cancer Centre Singapore and Singapore General Hospital, Republic of Singapore., Kow AWC; Division of Hepatobiliary & Pancreatic Surgery, Department of Surgery, University Surgical Cluster, National University Health System, Singapore 119228, Republic of Singapore., Leow WQ; Department of Pathology, Singapore General Hospital, Singapore 169608, Republic of Singapore., Jegannathan N; Department of Pathology, Singapore General Hospital, Singapore 169608, Republic of Singapore., Chen K; Department of Gastroenterology & Hepatology, Singapore General Hospital, Singapore 169608, Republic of Singapore., Bunchaliew C; Hepato-Pancreato-Biliary Surgery Unit, Department of Surgery, National Cancer Institute, Bangkok, Thailand., de Villa VH; Department of Surgery and Center for Liver Health and Transplantation, The Medical City, Pasig City, Metro Manila, Philippines., Koh PS; Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Bonney G; Division of Hepatobiliary & Pancreatic Surgery, Department of Surgery, University Surgical Cluster, National University Health System, Singapore 119228, Republic of Singapore., Goh BKP; Department of Hepatopancreatobiliary and Transplant Surgery, National Cancer Centre Singapore and Singapore General Hospital, Republic of Singapore., Tam WL; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome, Singapore 138672, Republic of Singapore; Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, Singapore 117599, Republic of Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (NUS), 8 Medical Drive, MD7, Singapore 117596, Republic of Singapore., Loo LH; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore., Yeong J; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore; Department of Anatomical Pathology, Singapore General Hospital, Republic of Singapore; Pathology Academic Clinical Program, Duke-NUS Medical School, Republic of Singapore; Department of Microbiology, Singapore General Hospital, Republic of Singapore., Tergaonkar V; Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore. Electronic address: vinayt@a-star.edu.sg., Chow PKH; Program in Translational and Clinical Liver Research, National Cancer Center Singapore, Republic of Singapore; Department of Hepatopancreatobiliary and Transplant Surgery, National Cancer Centre Singapore and Singapore General Hospital, Republic of Singapore; Surgery Academic Clinical Program, Duke-NUS Medical School, Singapore 169857, Republic of Singapore. Electronic address: pierce.chow@duke-nus.edu.sg.
Source: JHEP reports : innovation in hepatology [JHEP Rep] 2026 May; Vol. 8 (5), pp. 101790. Date of Electronic Publication: 2026 Feb 18.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101761237 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2589-5559 (Electronic) Linking ISSN: 25895559 NLM ISO Abbreviation: JHEP Rep Subsets: In Process
Database: MEDLINE Ultimate
Description
ISSN:2589-5559
DOI:10.1016/j.jhepr.2026.101790