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Multiomics and multi-region spatial transcriptome analysis reveal cellular networks and pathways associated with HCC recurrence.

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Title: Multiomics and multi-region spatial transcriptome analysis reveal cellular networks and pathways associated with HCC recurrence.
Authors: Seshachalam VP; Program in Translational and Clinical Liver Research, National Cancer Center Singapore, Republic of Singapore., Sari IN; Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Toh K; Program in Translational and Clinical Liver Research, National Cancer Center Singapore, Republic of Singapore., Majee P; Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Chong SL; Program in Translational and Clinical Liver Research, National Cancer Center Singapore, Republic of Singapore., Sekar K; Program in Translational and Clinical Liver Research, National Cancer Center Singapore, Republic of Singapore., Aiderus A; Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Idzham K; Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Qi OY; Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Chong LY; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore., Caldez M; Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Shanmugam R; Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Ying DHH; Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Lee E; Bioprocessing Technology Institute (BTI), Agency of Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore., Toh J; Bioprocessing Technology Institute (BTI), Agency of Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore., Lele W; Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Lee JYJ; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore., Zhong G; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore., Chew SC; Program in Translational and Clinical Liver Research, National Cancer Center Singapore, Republic of Singapore., Chen GB; Program in Translational and Clinical Liver Research, National Cancer Center Singapore, Republic of Singapore., Wu L; Program in Translational and Clinical Liver Research, National Cancer Center Singapore, Republic of Singapore., Chung AYF; Department of Hepatopancreatobiliary and Transplant Surgery, National Cancer Centre Singapore and Singapore General Hospital, Republic of Singapore., Cheow PC; Department of Hepatopancreatobiliary and Transplant Surgery, National Cancer Centre Singapore and Singapore General Hospital, Republic of Singapore., Kam JH; Department of Hepatopancreatobiliary and Transplant Surgery, National Cancer Centre Singapore and Singapore General Hospital, Republic of Singapore., Kow AWC; Division of Hepatobiliary & Pancreatic Surgery, Department of Surgery, University Surgical Cluster, National University Health System, Singapore 119228, Republic of Singapore., Leow WQ; Department of Pathology, Singapore General Hospital, Singapore 169608, Republic of Singapore., Jegannathan N; Department of Pathology, Singapore General Hospital, Singapore 169608, Republic of Singapore., Chen K; Department of Gastroenterology & Hepatology, Singapore General Hospital, Singapore 169608, Republic of Singapore., Bunchaliew C; Hepato-Pancreato-Biliary Surgery Unit, Department of Surgery, National Cancer Institute, Bangkok, Thailand., de Villa VH; Department of Surgery and Center for Liver Health and Transplantation, The Medical City, Pasig City, Metro Manila, Philippines., Koh PS; Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Bonney G; Division of Hepatobiliary & Pancreatic Surgery, Department of Surgery, University Surgical Cluster, National University Health System, Singapore 119228, Republic of Singapore., Goh BKP; Department of Hepatopancreatobiliary and Transplant Surgery, National Cancer Centre Singapore and Singapore General Hospital, Republic of Singapore., Tam WL; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome, Singapore 138672, Republic of Singapore; Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, Singapore 117599, Republic of Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (NUS), 8 Medical Drive, MD7, Singapore 117596, Republic of Singapore., Loo LH; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore., Yeong J; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore; Department of Anatomical Pathology, Singapore General Hospital, Republic of Singapore; Pathology Academic Clinical Program, Duke-NUS Medical School, Republic of Singapore; Department of Microbiology, Singapore General Hospital, Republic of Singapore., Tergaonkar V; Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore. Electronic address: vinayt@a-star.edu.sg., Chow PKH; Program in Translational and Clinical Liver Research, National Cancer Center Singapore, Republic of Singapore; Department of Hepatopancreatobiliary and Transplant Surgery, National Cancer Centre Singapore and Singapore General Hospital, Republic of Singapore; Surgery Academic Clinical Program, Duke-NUS Medical School, Singapore 169857, Republic of Singapore. Electronic address: pierce.chow@duke-nus.edu.sg.
Source: JHEP reports : innovation in hepatology [JHEP Rep] 2026 May; Vol. 8 (5), pp. 101790. Date of Electronic Publication: 2026 Feb 18.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101761237 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2589-5559 (Electronic) Linking ISSN: 25895559 NLM ISO Abbreviation: JHEP Rep Subsets: In Process
Database: MEDLINE Ultimate
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  Data: Multiomics and multi-region spatial transcriptome analysis reveal cellular networks and pathways associated with HCC recurrence.
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  Data: <searchLink fieldCode="AU" term="%22Seshachalam+VP%22">Seshachalam VP</searchLink>; Program in Translational and Clinical Liver Research, National Cancer Center Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Sari+IN%22">Sari IN</searchLink>; Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Toh+K%22">Toh K</searchLink>; Program in Translational and Clinical Liver Research, National Cancer Center Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Majee+P%22">Majee P</searchLink>; Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chong+SL%22">Chong SL</searchLink>; Program in Translational and Clinical Liver Research, National Cancer Center Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Sekar+K%22">Sekar K</searchLink>; Program in Translational and Clinical Liver Research, National Cancer Center Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Aiderus+A%22">Aiderus A</searchLink>; Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Idzham+K%22">Idzham K</searchLink>; Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Qi+OY%22">Qi OY</searchLink>; Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chong+LY%22">Chong LY</searchLink>; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Caldez+M%22">Caldez M</searchLink>; Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Shanmugam+R%22">Shanmugam R</searchLink>; Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ying+DHH%22">Ying DHH</searchLink>; Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lee+E%22">Lee E</searchLink>; Bioprocessing Technology Institute (BTI), Agency of Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Toh+J%22">Toh J</searchLink>; Bioprocessing Technology Institute (BTI), Agency of Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Lele+W%22">Lele W</searchLink>; Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lee+JYJ%22">Lee JYJ</searchLink>; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Zhong+G%22">Zhong G</searchLink>; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Chew+SC%22">Chew SC</searchLink>; Program in Translational and Clinical Liver Research, National Cancer Center Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Chen+GB%22">Chen GB</searchLink>; Program in Translational and Clinical Liver Research, National Cancer Center Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Wu+L%22">Wu L</searchLink>; Program in Translational and Clinical Liver Research, National Cancer Center Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Chung+AYF%22">Chung AYF</searchLink>; Department of Hepatopancreatobiliary and Transplant Surgery, National Cancer Centre Singapore and Singapore General Hospital, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Cheow+PC%22">Cheow PC</searchLink>; Department of Hepatopancreatobiliary and Transplant Surgery, National Cancer Centre Singapore and Singapore General Hospital, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Kam+JH%22">Kam JH</searchLink>; Department of Hepatopancreatobiliary and Transplant Surgery, National Cancer Centre Singapore and Singapore General Hospital, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Kow+AWC%22">Kow AWC</searchLink>; Division of Hepatobiliary & Pancreatic Surgery, Department of Surgery, University Surgical Cluster, National University Health System, Singapore 119228, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Leow+WQ%22">Leow WQ</searchLink>; Department of Pathology, Singapore General Hospital, Singapore 169608, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Jegannathan+N%22">Jegannathan N</searchLink>; Department of Pathology, Singapore General Hospital, Singapore 169608, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Chen+K%22">Chen K</searchLink>; Department of Gastroenterology & Hepatology, Singapore General Hospital, Singapore 169608, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Bunchaliew+C%22">Bunchaliew C</searchLink>; Hepato-Pancreato-Biliary Surgery Unit, Department of Surgery, National Cancer Institute, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22de+Villa+VH%22">de Villa VH</searchLink>; Department of Surgery and Center for Liver Health and Transplantation, The Medical City, Pasig City, Metro Manila, Philippines.<br /><searchLink fieldCode="AU" term="%22Koh+PS%22">Koh PS</searchLink>; Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.<br /><searchLink fieldCode="AU" term="%22Bonney+G%22">Bonney G</searchLink>; Division of Hepatobiliary & Pancreatic Surgery, Department of Surgery, University Surgical Cluster, National University Health System, Singapore 119228, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Goh+BKP%22">Goh BKP</searchLink>; Department of Hepatopancreatobiliary and Transplant Surgery, National Cancer Centre Singapore and Singapore General Hospital, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Tam+WL%22">Tam WL</searchLink>; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome, Singapore 138672, Republic of Singapore; Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, Singapore 117599, Republic of Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (NUS), 8 Medical Drive, MD7, Singapore 117596, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Loo+LH%22">Loo LH</searchLink>; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Yeong+J%22">Yeong J</searchLink>; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore; Department of Anatomical Pathology, Singapore General Hospital, Republic of Singapore; Pathology Academic Clinical Program, Duke-NUS Medical School, Republic of Singapore; Department of Microbiology, Singapore General Hospital, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Tergaonkar+V%22">Tergaonkar V</searchLink>; Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology and Research (A∗STAR), Singapore, Republic of Singapore. Electronic address: vinayt@a-star.edu.sg.<br /><searchLink fieldCode="AU" term="%22Chow+PKH%22">Chow PKH</searchLink>; Program in Translational and Clinical Liver Research, National Cancer Center Singapore, Republic of Singapore; Department of Hepatopancreatobiliary and Transplant Surgery, National Cancer Centre Singapore and Singapore General Hospital, Republic of Singapore; Surgery Academic Clinical Program, Duke-NUS Medical School, Singapore 169857, Republic of Singapore. Electronic address: pierce.chow@duke-nus.edu.sg.
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  Data: <searchLink fieldCode="JN" term="%22101761237%22">JHEP reports : innovation in hepatology</searchLink> [JHEP Rep] 2026 May; Vol. 8 (5), pp. 101790. <i>Date of Electronic Publication: </i>2026 Feb 18.
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