Neoadjuvant palbociclib and endocrine therapy versus chemotherapy in ER + /HER2- breast cancer: a randomized phase II trial.
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| Title: | Neoadjuvant palbociclib and endocrine therapy versus chemotherapy in ER + /HER2- breast cancer: a randomized phase II trial. |
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| Authors: | Matikas A; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden. alexios.matikas@ki.se.; Breast Center, Karolinska Comprehensive Cancer Center (KCCC), Stockholm, Sweden. alexios.matikas@ki.se., Tzoras E; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden., Sarafidis M; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden., Sifakis EG; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden., Bjöhle J; Breast Center, Karolinska Comprehensive Cancer Center (KCCC), Stockholm, Sweden., Barnekow E; Department of Oncology, Södersjukhuset, Stockholm, Sweden.; Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden., Margolin S; Department of Oncology, Södersjukhuset, Stockholm, Sweden.; Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden., Isaksson-Friman E; Breast Center, St Göran Hospital, Stockholm, Sweden., Kessler LE; Breast Center, St Göran Hospital, Stockholm, Sweden., Zouzos A; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden., Johansson H; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden., Hellström M; Breast Center, Karolinska Comprehensive Cancer Center (KCCC), Stockholm, Sweden., Agartz S; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden., Grybäck P; Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden., Salgkamis D; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden., Zerdes I; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden., Wang K; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden., Hartman J; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden.; Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden., Acs B; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden.; Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden., Sun W; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden.; Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden., Boyaci C; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden.; Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden., Villacampa G; SOLTI Cancer Research Group, Barcelona, Spain.; Statistics Unit, Vall d'Hebron Institute of Oncology, Barcelona, Spain., Pascual T; SOLTI Cancer Research Group, Barcelona, Spain.; Translational Genomics and Targeted Therapies in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.; Medical Oncology Department, Hospital Clinic of Barcelona, Barcelona, Spain.; Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain., Gavila J; SOLTI Cancer Research Group, Barcelona, Spain.; Department of Medical Oncology, Instituto Valenciano de Oncología, Valencia, Spain., Prat A; Translational Genomics and Targeted Therapies in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.; Medical Oncology Department, Hospital Clinic of Barcelona, Barcelona, Spain.; Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain., Perou C; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Brandberg Y; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden., Bergh J; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden.; Breast Center, Karolinska Comprehensive Cancer Center (KCCC), Stockholm, Sweden., Hatschek T; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden.; Breast Center, Karolinska Comprehensive Cancer Center (KCCC), Stockholm, Sweden., Foukakis T; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden. theodoros.foukakis@ki.se.; Breast Center, Karolinska Comprehensive Cancer Center (KCCC), Stockholm, Sweden. theodoros.foukakis@ki.se. |
| Source: | Nature communications [Nat Commun] 2026 Apr 08; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 08. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-026-71452-6 |
