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Neoadjuvant palbociclib and endocrine therapy versus chemotherapy in ER + /HER2- breast cancer: a randomized phase II trial.

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Title: Neoadjuvant palbociclib and endocrine therapy versus chemotherapy in ER + /HER2- breast cancer: a randomized phase II trial.
Authors: Matikas A; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden. alexios.matikas@ki.se.; Breast Center, Karolinska Comprehensive Cancer Center (KCCC), Stockholm, Sweden. alexios.matikas@ki.se., Tzoras E; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden., Sarafidis M; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden., Sifakis EG; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden., Bjöhle J; Breast Center, Karolinska Comprehensive Cancer Center (KCCC), Stockholm, Sweden., Barnekow E; Department of Oncology, Södersjukhuset, Stockholm, Sweden.; Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden., Margolin S; Department of Oncology, Södersjukhuset, Stockholm, Sweden.; Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden., Isaksson-Friman E; Breast Center, St Göran Hospital, Stockholm, Sweden., Kessler LE; Breast Center, St Göran Hospital, Stockholm, Sweden., Zouzos A; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden., Johansson H; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden., Hellström M; Breast Center, Karolinska Comprehensive Cancer Center (KCCC), Stockholm, Sweden., Agartz S; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden., Grybäck P; Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden., Salgkamis D; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden., Zerdes I; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden., Wang K; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden., Hartman J; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden.; Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden., Acs B; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden.; Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden., Sun W; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden.; Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden., Boyaci C; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden.; Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden., Villacampa G; SOLTI Cancer Research Group, Barcelona, Spain.; Statistics Unit, Vall d'Hebron Institute of Oncology, Barcelona, Spain., Pascual T; SOLTI Cancer Research Group, Barcelona, Spain.; Translational Genomics and Targeted Therapies in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.; Medical Oncology Department, Hospital Clinic of Barcelona, Barcelona, Spain.; Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain., Gavila J; SOLTI Cancer Research Group, Barcelona, Spain.; Department of Medical Oncology, Instituto Valenciano de Oncología, Valencia, Spain., Prat A; Translational Genomics and Targeted Therapies in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.; Medical Oncology Department, Hospital Clinic of Barcelona, Barcelona, Spain.; Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain., Perou C; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Brandberg Y; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden., Bergh J; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden.; Breast Center, Karolinska Comprehensive Cancer Center (KCCC), Stockholm, Sweden., Hatschek T; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden.; Breast Center, Karolinska Comprehensive Cancer Center (KCCC), Stockholm, Sweden., Foukakis T; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden. theodoros.foukakis@ki.se.; Breast Center, Karolinska Comprehensive Cancer Center (KCCC), Stockholm, Sweden. theodoros.foukakis@ki.se.
Source: Nature communications [Nat Commun] 2026 Apr 08; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 08.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Neoadjuvant palbociclib and endocrine therapy versus chemotherapy in ER + /HER2- breast cancer: a randomized phase II trial.
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  Data: <searchLink fieldCode="AU" term="%22Matikas+A%22">Matikas A</searchLink>; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden. alexios.matikas@ki.se.; Breast Center, Karolinska Comprehensive Cancer Center (KCCC), Stockholm, Sweden. alexios.matikas@ki.se.<br /><searchLink fieldCode="AU" term="%22Tzoras+E%22">Tzoras E</searchLink>; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Sarafidis+M%22">Sarafidis M</searchLink>; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Sifakis+EG%22">Sifakis EG</searchLink>; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Bjöhle+J%22">Bjöhle J</searchLink>; Breast Center, Karolinska Comprehensive Cancer Center (KCCC), Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Barnekow+E%22">Barnekow E</searchLink>; Department of Oncology, Södersjukhuset, Stockholm, Sweden.; Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Margolin+S%22">Margolin S</searchLink>; Department of Oncology, Södersjukhuset, Stockholm, Sweden.; Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Isaksson-Friman+E%22">Isaksson-Friman E</searchLink>; Breast Center, St Göran Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Kessler+LE%22">Kessler LE</searchLink>; Breast Center, St Göran Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Zouzos+A%22">Zouzos A</searchLink>; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Johansson+H%22">Johansson H</searchLink>; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Hellström+M%22">Hellström M</searchLink>; Breast Center, Karolinska Comprehensive Cancer Center (KCCC), Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Agartz+S%22">Agartz S</searchLink>; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Grybäck+P%22">Grybäck P</searchLink>; Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Salgkamis+D%22">Salgkamis D</searchLink>; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Zerdes+I%22">Zerdes I</searchLink>; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Wang+K%22">Wang K</searchLink>; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Hartman+J%22">Hartman J</searchLink>; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden.; Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Acs+B%22">Acs B</searchLink>; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden.; Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Sun+W%22">Sun W</searchLink>; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden.; Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Boyaci+C%22">Boyaci C</searchLink>; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden.; Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Villacampa+G%22">Villacampa G</searchLink>; SOLTI Cancer Research Group, Barcelona, Spain.; 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Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Perou+C%22">Perou C</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Brandberg+Y%22">Brandberg Y</searchLink>; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Bergh+J%22">Bergh J</searchLink>; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden.; Breast Center, Karolinska Comprehensive Cancer Center (KCCC), Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Hatschek+T%22">Hatschek T</searchLink>; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden.; Breast Center, Karolinska Comprehensive Cancer Center (KCCC), Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Foukakis+T%22">Foukakis T</searchLink>; Oncology-Pathology Department, Karolinska Institutet, Stockholm, Sweden. theodoros.foukakis@ki.se.; Breast Center, Karolinska Comprehensive Cancer Center (KCCC), Stockholm, Sweden. theodoros.foukakis@ki.se.
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