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High-throughput screening identifies NT-1 that synergizes with MRTX1133 against acquired resistant KRASG12D colorectal cancer.

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Title: High-throughput screening identifies NT-1 that synergizes with MRTX1133 against acquired resistant KRASG12D colorectal cancer.
Authors: Thielen N; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York, NY, USA.; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, NY, USA.; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, NY, USA., Wei N; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York, NY, USA. ning.wei@einsteinmed.edu.; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, NY, USA. ning.wei@einsteinmed.edu.; Department of Oncology, Albert Einstein College of Medicine, Bronx, New York, NY, USA. ning.wei@einsteinmed.edu., Nagai E; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York, NY, USA.; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, NY, USA., Houston M; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York, NY, USA.; Department of Oncology, Albert Einstein College of Medicine, Bronx, New York, NY, USA.; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, NY, USA., Augenlicht LH; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York, NY, USA.; Department of Oncology, Albert Einstein College of Medicine, Bronx, New York, NY, USA.; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, NY, USA., Shin AE; Division of Digestive and Liver Diseases, Department of Medicine, Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, USA., Gabre JT; Division of Digestive and Liver Diseases, Department of Medicine, Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, USA., Rustgi AK; Division of Digestive and Liver Diseases, Department of Medicine, Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, USA., Ha G; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York, NY, USA.; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, NY, USA., LaFave LM; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York, NY, USA.; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, NY, USA., Chu E; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York, NY, USA.; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, NY, USA.; Department of Oncology, Albert Einstein College of Medicine, Bronx, New York, NY, USA., Kitamura S; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York, NY, USA. seiya.kitamura@einsteinmed.edu.; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, NY, USA. seiya.kitamura@einsteinmed.edu., Kuang C; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York, NY, USA. chaoyuan.kuang@einsteinmed.edu.; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, NY, USA. chaoyuan.kuang@einsteinmed.edu.; Department of Oncology, Albert Einstein College of Medicine, Bronx, New York, NY, USA. chaoyuan.kuang@einsteinmed.edu.
Source: NPJ precision oncology [NPJ Precis Oncol] 2026 Apr 08; Vol. 10 (1). Date of Electronic Publication: 2026 Apr 08.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101708166 Publication Model: Electronic Cited Medium: Print ISSN: 2397-768X (Print) Linking ISSN: 2397768X NLM ISO Abbreviation: NPJ Precis Oncol Subsets: PubMed not MEDLINE
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  Data: High-throughput screening identifies NT-1 that synergizes with MRTX1133 against acquired resistant KRAS<superscript>G12D</superscript> colorectal cancer.
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  Data: <searchLink fieldCode="AU" term="%22Thielen+N%22">Thielen N</searchLink>; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York, NY, USA.; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, NY, USA.; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Wei+N%22">Wei N</searchLink>; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York, NY, USA. ning.wei@einsteinmed.edu.; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, NY, USA. ning.wei@einsteinmed.edu.; Department of Oncology, Albert Einstein College of Medicine, Bronx, New York, NY, USA. ning.wei@einsteinmed.edu.<br /><searchLink fieldCode="AU" term="%22Nagai+E%22">Nagai E</searchLink>; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York, NY, USA.; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Houston+M%22">Houston M</searchLink>; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York, NY, USA.; Department of Oncology, Albert Einstein College of Medicine, Bronx, New York, NY, USA.; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Augenlicht+LH%22">Augenlicht LH</searchLink>; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York, NY, USA.; Department of Oncology, Albert Einstein College of Medicine, Bronx, New York, NY, USA.; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Shin+AE%22">Shin AE</searchLink>; Division of Digestive and Liver Diseases, Department of Medicine, Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, USA.<br /><searchLink fieldCode="AU" term="%22Gabre+JT%22">Gabre JT</searchLink>; Division of Digestive and Liver Diseases, Department of Medicine, Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, USA.<br /><searchLink fieldCode="AU" term="%22Rustgi+AK%22">Rustgi AK</searchLink>; Division of Digestive and Liver Diseases, Department of Medicine, Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, USA.<br /><searchLink fieldCode="AU" term="%22Ha+G%22">Ha G</searchLink>; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York, NY, USA.; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22LaFave+LM%22">LaFave LM</searchLink>; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York, NY, USA.; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Chu+E%22">Chu E</searchLink>; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York, NY, USA.; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, NY, USA.; Department of Oncology, Albert Einstein College of Medicine, Bronx, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kitamura+S%22">Kitamura S</searchLink>; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York, NY, USA. seiya.kitamura@einsteinmed.edu.; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, NY, USA. seiya.kitamura@einsteinmed.edu.<br /><searchLink fieldCode="AU" term="%22Kuang+C%22">Kuang C</searchLink>; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York, NY, USA. chaoyuan.kuang@einsteinmed.edu.; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, NY, USA. chaoyuan.kuang@einsteinmed.edu.; Department of Oncology, Albert Einstein College of Medicine, Bronx, New York, NY, USA. chaoyuan.kuang@einsteinmed.edu.
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  Data: <searchLink fieldCode="JN" term="%22101708166%22">NPJ precision oncology</searchLink> [NPJ Precis Oncol] 2026 Apr 08; Vol. 10 (1). <i>Date of Electronic Publication: </i>2026 Apr 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Nature%22">Springer Nature </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101708166 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2397-768X (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222397768X%22">2397768X </searchLink><i>NLM ISO Abbreviation: </i>NPJ Precis Oncol <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1038/s41698-026-01384-3
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