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Sialylated CD43 forms a glyco-immune barrier that restrains antileukemic immunity.

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Title: Sialylated CD43 forms a glyco-immune barrier that restrains antileukemic immunity.
Authors: Chung J; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.; Division of Hematology and Oncology, Massachusetts General Brigham Cancer Center, Boston, MA, USA., Vallurupalli M; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Noel S; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Schor G; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Mrowka S; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Scapozza I; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Demere Z; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Kammula SV; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Hu M; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Kim SY; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Liu Y; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Nobrega C; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Perera JJ; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Wrona E; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Clinical and Laboratory Genetics, Medical University of Lodz, Lodz, Poland.; Department of Chemotherapy, Copernicus Memorial Hospital, Lodz, Poland., Cheruiyot CK; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA., Lin Y; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Wu DW; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Saberi M; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Cruickshank A; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Woods EC; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.; Division of Hematology and Oncology, Massachusetts General Brigham Cancer Center, Boston, MA, USA., Chuong CL; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Birocchi F; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA., Kammula AV; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Avila OI; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Knudsen N; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Kocak M; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Doench JG; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Procter D; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Thornton L; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Brunner AM; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.; Division of Hematology and Oncology, Massachusetts General Brigham Cancer Center, Boston, MA, USA., Winer E; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., DeAngelo DJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Garcia JS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Stone RM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Jenkins RW; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.; Division of Hematology and Oncology, Massachusetts General Brigham Cancer Center, Boston, MA, USA., Maus MV; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.; Division of Hematology and Oncology, Massachusetts General Brigham Cancer Center, Boston, MA, USA., Graubert TA; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.; Division of Hematology and Oncology, Massachusetts General Brigham Cancer Center, Boston, MA, USA., Yates KB; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA., Golub TR; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Manguso RT; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Source: Science (New York, N.Y.) [Science] 2026 Apr 09; Vol. 392 (6794), pp. eady5196. Date of Electronic Publication: 2026 Apr 09.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1095-9203
DOI:10.1126/science.ady5196