CD18-targeted peptide-drug conjugate remodels the immunosuppressive tumor microenvironment of prostate cancer by selective depletion of M2 macrophages.

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Title: CD18-targeted peptide-drug conjugate remodels the immunosuppressive tumor microenvironment of prostate cancer by selective depletion of M2 macrophages.
Authors: Han IH; Department of Physiology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea., Choi I; Department of Physiology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea., Kim S; Twinpig Biolab Inc. R&D Center, Seoul, Republic of Korea., Lee H; Twinpig Biolab Inc. R&D Center, Seoul, Republic of Korea., Kwon M; Department of Physiology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea., Lee WJ; Department of Physiology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea., Bae H; Department of Physiology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea. hbae@khu.ac.kr.
Source: NPJ precision oncology [NPJ Precis Oncol] 2026 Apr 09; Vol. 10 (1). Date of Electronic Publication: 2026 Apr 09.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101708166 Publication Model: Electronic Cited Medium: Print ISSN: 2397-768X (Print) Linking ISSN: 2397768X NLM ISO Abbreviation: NPJ Precis Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:2397-768X
DOI:10.1038/s41698-026-01377-2