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DNA damage drives a unique, Alzheimer's disease-relevant senescent state in neurons.

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Title: DNA damage drives a unique, Alzheimer's disease-relevant senescent state in neurons.
Authors: Hughes JB; Buck Institute for Research on Aging, Novato, CA, USA.; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA., Sandholm A; Buck Institute for Research on Aging, Novato, CA, USA., Croll D; Buck Institute for Research on Aging, Novato, CA, USA., Senchyna F; Buck Institute for Research on Aging, Novato, CA, USA., Schneider K; Buck Institute for Research on Aging, Novato, CA, USA., Butterfield R; Buck Institute for Research on Aging, Novato, CA, USA., McHugh TLM; Buck Institute for Research on Aging, Novato, CA, USA.; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA., Brown I; Buck Institute for Research on Aging, Novato, CA, USA., Deguchi H; Buck Institute for Research on Aging, Novato, CA, USA., Hilsabeck TAU; Buck Institute for Research on Aging, Novato, CA, USA., Mak S; Buck Institute for Research on Aging, Novato, CA, USA., Wilson KA; Buck Institute for Research on Aging, Novato, CA, USA., Davtyan H; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA., Blurton-Jones M; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA., Herdy J; The Salk Institute for Biological Studies, La Jolla, CA, USA., Higuchi-Sanabria R; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA., Gage FH; The Salk Institute for Biological Studies, La Jolla, CA, USA., Furman D; Buck Institute for Research on Aging, Novato, CA, USA., Ellerby LM; Buck Institute for Research on Aging, Novato, CA, USA.; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA., Desprez PY; Buck Institute for Research on Aging, Novato, CA, USA.; California Pacific Medical Center, Research Institute, San Francisco, California, USA., Campisi J; Buck Institute for Research on Aging, Novato, CA, USA.; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Apr 03. Date of Electronic Publication: 2026 Apr 03.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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An: 41959128
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PubType: Academic Journal
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  Data: DNA damage drives a unique, Alzheimer's disease-relevant senescent state in neurons.
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  Data: <searchLink fieldCode="AU" term="%22Hughes+JB%22">Hughes JB</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sandholm+A%22">Sandholm A</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.<br /><searchLink fieldCode="AU" term="%22Croll+D%22">Croll D</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.<br /><searchLink fieldCode="AU" term="%22Senchyna+F%22">Senchyna F</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.<br /><searchLink fieldCode="AU" term="%22Schneider+K%22">Schneider K</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.<br /><searchLink fieldCode="AU" term="%22Butterfield+R%22">Butterfield R</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.<br /><searchLink fieldCode="AU" term="%22McHugh+TLM%22">McHugh TLM</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Brown+I%22">Brown I</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.<br /><searchLink fieldCode="AU" term="%22Deguchi+H%22">Deguchi H</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hilsabeck+TAU%22">Hilsabeck TAU</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mak+S%22">Mak S</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+KA%22">Wilson KA</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.<br /><searchLink fieldCode="AU" term="%22Davtyan+H%22">Davtyan H</searchLink>; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Blurton-Jones+M%22">Blurton-Jones M</searchLink>; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Herdy+J%22">Herdy J</searchLink>; The Salk Institute for Biological Studies, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Higuchi-Sanabria+R%22">Higuchi-Sanabria R</searchLink>; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gage+FH%22">Gage FH</searchLink>; The Salk Institute for Biological Studies, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Furman+D%22">Furman D</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ellerby+LM%22">Ellerby LM</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Desprez+PY%22">Desprez PY</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.; California Pacific Medical Center, Research Institute, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Campisi+J%22">Campisi J</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
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