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Histone decrotonylation plays a distinct role in HIV latency.

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Title: Histone decrotonylation plays a distinct role in HIV latency.
Authors: Li X; UNC HIV Cure Center, University of North Carolina, Chapel Hill, NC 27599, USA.; Institute of Global Health & Infectious Diseases, University of North Carolina, Chapel Hill, NC 27599, USA., Li D; UNC HIV Cure Center, University of North Carolina, Chapel Hill, NC 27599, USA.; Institute of Global Health & Infectious Diseases, University of North Carolina, Chapel Hill, NC 27599, USA., Tang Y; UNC HIV Cure Center, University of North Carolina, Chapel Hill, NC 27599, USA.; Institute of Global Health & Infectious Diseases, University of North Carolina, Chapel Hill, NC 27599, USA., Nearing M; Department of Medical Microbiology and Immunology, University of California, Davis, CA 95616, USA., Varco-Merth B; Vaccine & Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA., Chen H; UNC HIV Cure Center, University of North Carolina, Chapel Hill, NC 27599, USA.; Institute of Global Health & Infectious Diseases, University of North Carolina, Chapel Hill, NC 27599, USA., Smith D; Department of Medicine, University of California, San Diego, CA 92093, USA., Gianella S; Department of Medicine, University of California, San Diego, CA 92093, USA., Archin NM; UNC HIV Cure Center, University of North Carolina, Chapel Hill, NC 27599, USA.; Institute of Global Health & Infectious Diseases, University of North Carolina, Chapel Hill, NC 27599, USA., Okoye AA; Vaccine & Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA., Dandekar S; Department of Medical Microbiology and Immunology, University of California, Davis, CA 95616, USA., Margolis DM; UNC HIV Cure Center, University of North Carolina, Chapel Hill, NC 27599, USA.; Institute of Global Health & Infectious Diseases, University of North Carolina, Chapel Hill, NC 27599, USA.; Department of Microbiology and Immunology, University of North Carolina School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA., Chirasani VR; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA.; R. L. Juliano Structural Bioinformatics Core, University of North Carolina, Chapel Hill, NC 27599, USA., Gumpper RH; UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA., Jiang G; UNC HIV Cure Center, University of North Carolina, Chapel Hill, NC 27599, USA.; Institute of Global Health & Infectious Diseases, University of North Carolina, Chapel Hill, NC 27599, USA.; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA.
Source: Science advances [Sci Adv] 2026 Apr 10; Vol. 12 (15), pp. eaec0149. Date of Electronic Publication: 2026 Apr 10.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; UNC HIV Cure Center, University of North Carolina, Chapel Hill, NC 27599, USA.; Institute of Global Health & Infectious Diseases, University of North Carolina, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Li+D%22">Li D</searchLink>; UNC HIV Cure Center, University of North Carolina, Chapel Hill, NC 27599, USA.; Institute of Global Health & Infectious Diseases, University of North Carolina, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Tang+Y%22">Tang Y</searchLink>; UNC HIV Cure Center, University of North Carolina, Chapel Hill, NC 27599, USA.; Institute of Global Health & Infectious Diseases, University of North Carolina, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Nearing+M%22">Nearing M</searchLink>; Department of Medical Microbiology and Immunology, University of California, Davis, CA 95616, USA.<br /><searchLink fieldCode="AU" term="%22Varco-Merth+B%22">Varco-Merth B</searchLink>; Vaccine & Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; UNC HIV Cure Center, University of North Carolina, Chapel Hill, NC 27599, USA.; Institute of Global Health & Infectious Diseases, University of North Carolina, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Smith+D%22">Smith D</searchLink>; Department of Medicine, University of California, San Diego, CA 92093, USA.<br /><searchLink fieldCode="AU" term="%22Gianella+S%22">Gianella S</searchLink>; Department of Medicine, University of California, San Diego, CA 92093, USA.<br /><searchLink fieldCode="AU" term="%22Archin+NM%22">Archin NM</searchLink>; UNC HIV Cure Center, University of North Carolina, Chapel Hill, NC 27599, USA.; Institute of Global Health & Infectious Diseases, University of North Carolina, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Okoye+AA%22">Okoye AA</searchLink>; Vaccine & Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA.<br /><searchLink fieldCode="AU" term="%22Dandekar+S%22">Dandekar S</searchLink>; Department of Medical Microbiology and Immunology, University of California, Davis, CA 95616, USA.<br /><searchLink fieldCode="AU" term="%22Margolis+DM%22">Margolis DM</searchLink>; UNC HIV Cure Center, University of North Carolina, Chapel Hill, NC 27599, USA.; Institute of Global Health & Infectious Diseases, University of North Carolina, Chapel Hill, NC 27599, USA.; Department of Microbiology and Immunology, University of North Carolina School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA.<br /><searchLink fieldCode="AU" term="%22Chirasani+VR%22">Chirasani VR</searchLink>; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA.; R. L. Juliano Structural Bioinformatics Core, University of North Carolina, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Gumpper+RH%22">Gumpper RH</searchLink>; UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Jiang+G%22">Jiang G</searchLink>; UNC HIV Cure Center, University of North Carolina, Chapel Hill, NC 27599, USA.; Institute of Global Health & Infectious Diseases, University of North Carolina, Chapel Hill, NC 27599, USA.; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA.
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