Asy-RPA/PCR combined with One-crRNA-CRISPR/Cas12a for simultaneous detection of multiple Clarithromycin resistance mutations in Helicobacter pylori.

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Title: Asy-RPA/PCR combined with One-crRNA-CRISPR/Cas12a for simultaneous detection of multiple Clarithromycin resistance mutations in Helicobacter pylori.
Authors: Liu Y; Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Laboratory Medicine, Nanjing Jiangning Hospital of Chinese Medicine, Nanjing, China., Chen S; Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Laboratory Medicine, Nanjing Jiangning Hospital of Chinese Medicine, Nanjing, China., Zhang C; Affiliated Jiangning Hospital of Chinese Medicine, China Pharmaceutical University, Nanjing, China., Xue H; Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Laboratory Medicine, Taizhou Hospital of Traditional Chinese Medicine, Taizhou, China., Abubakar MU; Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China., Yin S; Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Laboratory Medicine, Yangzhou Hongquan Hospital, Yangzhou, China., Yang X; Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China., Fan B; Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China., Tai P; Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China., Xiong M; Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. Electronic address: mengqiuxiong@163.com., Li J; Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. Electronic address: lijingjing_li@163.com., He B; Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China; H. pylori Research Key Laboratory, Nanjing Medical University, Nanjing, China. Electronic address: bhe@njmu.edu.cn.
Source: Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2026 Jun; Vol. 74, pp. 102942. Date of Electronic Publication: 2026 Apr 08.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101233142 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-9642 (Electronic) Linking ISSN: 15499634 NLM ISO Abbreviation: Nanomedicine Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1549-9642
DOI:10.1016/j.nano.2026.102942