The H3K36me3 methyltransferase SETD2 contributes to PAF1C interactions with RNA Pol II and is required for neuronal differentiation.
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| Title: | The H3K36me3 methyltransferase SETD2 contributes to PAF1C interactions with RNA Pol II and is required for neuronal differentiation. |
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| Authors: | Ambrosi C; Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.; Life Science Zurich Graduate School, University of Zurich and ETH Zurich, Zurich, Switzerland., Pfaendler R; Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.; Life Science Zurich Graduate School, University of Zurich and ETH Zurich, Zurich, Switzerland.; Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland., Eleftheriou K; Genome Biology and Epigenetics, Institute of Biodynamics and Biocomplexity, Department of Biology, Utrecht University, Utrecht, The Netherlands., Butz S; Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.; Life Science Zurich Graduate School, University of Zurich and ETH Zurich, Zurich, Switzerland., Recchia D; Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.; Life Science Zurich Graduate School, University of Zurich and ETH Zurich, Zurich, Switzerland.; Genome Biology and Epigenetics, Institute of Biodynamics and Biocomplexity, Department of Biology, Utrecht University, Utrecht, The Netherlands., Bao X; Genome Biology and Epigenetics, Institute of Biodynamics and Biocomplexity, Department of Biology, Utrecht University, Utrecht, The Netherlands., Cardoso da Silva R; Genome Biology and Epigenetics, Institute of Biodynamics and Biocomplexity, Department of Biology, Utrecht University, Utrecht, The Netherlands., Kupfer N; Genome Biology and Epigenetics, Institute of Biodynamics and Biocomplexity, Department of Biology, Utrecht University, Utrecht, The Netherlands., Lagerwaard IM; Genome Biology and Epigenetics, Institute of Biodynamics and Biocomplexity, Department of Biology, Utrecht University, Utrecht, The Netherlands., Vlaming H; Genome Biology and Epigenetics, Institute of Biodynamics and Biocomplexity, Department of Biology, Utrecht University, Utrecht, The Netherlands., Schmolka N; Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Bhardwaj V; Genome Biology and Epigenetics, Institute of Biodynamics and Biocomplexity, Department of Biology, Utrecht University, Utrecht, The Netherlands., Baubec T; Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland. t.baubec@uu.nl.; Genome Biology and Epigenetics, Institute of Biodynamics and Biocomplexity, Department of Biology, Utrecht University, Utrecht, The Netherlands. t.baubec@uu.nl. |
| Source: | The EMBO journal [EMBO J] 2026 May; Vol. 45 (10), pp. 3430-3443. Date of Electronic Publication: 2026 Apr 10. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1460-2075 |
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| DOI: | 10.1038/s44318-026-00768-2 |
