Senescence-like cells recruit γδ T cells to drive prolonged hyposmia after SARS-CoV-2 infection in mice.

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Title: Senescence-like cells recruit γδ T cells to drive prolonged hyposmia after SARS-CoV-2 infection in mice.
Authors: Tsuji S; Department of Molecular Biology, Research Institute for Microbial Diseases, The University of Osaka, Suita, Japan. stsuji@biken.osaka-u.ac.jp.; Department of Pharmacology, Yamaguchi University Graduate School of Medicine, Ube, Japan. stsuji@biken.osaka-u.ac.jp., Nakano S; Department of Molecular Biology, Research Institute for Microbial Diseases, The University of Osaka, Suita, Japan., Ito K; Department of Molecular Biology, Research Institute for Microbial Diseases, The University of Osaka, Suita, Japan., Minami S; Department of Virology, Research Institute for Microbial Diseases, The University of Osaka, Suita, Japan., Uemura K; Department of Molecular Biology, Research Institute for Microbial Diseases, The University of Osaka, Suita, Japan., Konishi Y; Department of Molecular Biology, Research Institute for Microbial Diseases, The University of Osaka, Suita, Japan., Wakita M; Department of Molecular Biology, Research Institute for Microbial Diseases, The University of Osaka, Suita, Japan., Okumura Y; Department of Molecular Biology, Research Institute for Microbial Diseases, The University of Osaka, Suita, Japan., Kawamoto S; Department of Molecular Biology, Research Institute for Microbial Diseases, The University of Osaka, Suita, Japan.; HealthSpan Research Center, Tohoku University, Sendai, Japan.; Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.; Organization for Advanced Studies, Tohoku University, Sendai, Japan., Matsuki A; Graduate School of Life Science, Hokkaido University, Sapporo, Japan., Nakaoka S; Graduate School of Life Science, Hokkaido University, Sapporo, Japan., Ono C; Laboratory of Virus Control, Research Institute for Microbial Diseases, The University of Osaka, Suita, Japan.; Center for Infectious Disease Education and Research, The University of Osaka, Suita, Japan., Takahashi H; Department of Molecular Neurobiology, Graduate School of Medicine, Kagawa University, Kagawa, Japan., Anzai I; Department of Molecular Virology, Research Institute for Microbial Diseases, The University of Osaka, Suita, Japan., Watanabe T; Center for Infectious Disease Education and Research, The University of Osaka, Suita, Japan.; Department of Molecular Virology, Research Institute for Microbial Diseases, The University of Osaka, Suita, Japan., Uezumi A; Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan., Matsuura Y; Laboratory of Virus Control, Research Institute for Microbial Diseases, The University of Osaka, Suita, Japan.; Center for Infectious Disease Education and Research, The University of Osaka, Suita, Japan., Kobayashi T; Department of Virology, Research Institute for Microbial Diseases, The University of Osaka, Suita, Japan.; Center for Infectious Disease Education and Research, The University of Osaka, Suita, Japan., Okamoto T; Juntendo University School of Medicine, Tokyo, Japan., Tsuboi A; Graduate School of Pharmaceutical Sciences, The University of Osaka, Suita, Japan. tsuboi-a@phs.osaka-u.ac.jp., Asagiri M; Department of Pharmacology, Yamaguchi University Graduate School of Medicine, Ube, Japan., Hara E; Department of Molecular Biology, Research Institute for Microbial Diseases, The University of Osaka, Suita, Japan. ehara@biken.osaka-u.ac.jp.; Center for Infectious Disease Education and Research, The University of Osaka, Suita, Japan. ehara@biken.osaka-u.ac.jp.; Immunology Frontier Research Center, The University of Osaka, Suita, Japan. ehara@biken.osaka-u.ac.jp.
Source: EMBO reports [EMBO Rep] 2026 May; Vol. 27 (10), pp. 2526-2548. Date of Electronic Publication: 2026 Apr 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1469-3178
DOI:10.1038/s44319-026-00769-6