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Hexokinase 3 promoted cytokine production of monocytes by targeting metabolic reprogramming and histone lactylation in sepsis.

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Title: Hexokinase 3 promoted cytokine production of monocytes by targeting metabolic reprogramming and histone lactylation in sepsis.
Authors: Lian C; Department of Emergency, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, People's Republic of China., Xu Q; Department of Emergency, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, People's Republic of China., Shi H; Department of Emergency, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, People's Republic of China., Xie Y; Department of Emergency, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, People's Republic of China., Fang J; Department of Emergency, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, People's Republic of China., Rao B; Department of Emergency, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, People's Republic of China., Ji T; State Key Laboratory of Respiratory Disease, Clinical Laboratory Medicine Department, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, People's Republic of China., Jiang H; Department of Emergency, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, People's Republic of China., Wu Z; Department of Emergency, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, People's Republic of China. 21490416@qq.com., Chen XH; Department of Emergency, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, People's Republic of China. cxhgz168paper@163.com., Lin SP; Department of Emergency, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, People's Republic of China. linsp@qq.com.
Source: Clinical epigenetics [Clin Epigenetics] 2026 Apr 10; Vol. 18 (1). Date of Electronic Publication: 2026 Apr 10.
Publication Type: Journal Article
Journal Info: Publisher: Biomed Central Country of Publication: Germany NLM ID: 101516977 Publication Model: Electronic Cited Medium: Internet ISSN: 1868-7083 (Electronic) Linking ISSN: 18687075 NLM ISO Abbreviation: Clin Epigenetics Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1868-7083
DOI:10.1186/s13148-026-02129-6