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Novel paracellular marker based on ᴅ-dipeptide structure for highly sensitive quantification with UPLC-MS/MS for in vitro and in vivo blood-brain barrier permeability analysis.

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Title: Novel paracellular marker based on ᴅ-dipeptide structure for highly sensitive quantification with UPLC-MS/MS for in vitro and in vivo blood-brain barrier permeability analysis.
Authors: Bay C; Department of Clinical Pharmacology and Pharmacoepidemiology, Internal Medicine IX, Heidelberg University, Medical Faculty Heidelberg / Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany., Mühlberg E; Department of Nuclear Medicine, Heidelberg University, Medical Faculty Heidelberg / Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.; Department of Pharmaceutical Technology and Biopharmacy, Institute for Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 329, 69120, Heidelberg, Germany., Uhl P; Department of Pharmaceutical Technology and Biopharmacy, Institute for Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 329, 69120, Heidelberg, Germany., Stingl JC; Department of Clinical Pharmacology and Pharmacoepidemiology, Internal Medicine IX, Heidelberg University, Medical Faculty Heidelberg / Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany., Bajraktari-Sylejmani G; Department of Clinical Pharmacology and Pharmacoepidemiology, Internal Medicine IX, Heidelberg University, Medical Faculty Heidelberg / Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany., Burhenne J; Department of Clinical Pharmacology and Pharmacoepidemiology, Internal Medicine IX, Heidelberg University, Medical Faculty Heidelberg / Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany., Weiss J; Department of Clinical Pharmacology and Pharmacoepidemiology, Internal Medicine IX, Heidelberg University, Medical Faculty Heidelberg / Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany. johanna.weiss@med.uni-heidelberg.de., Sauter M; Department of Clinical Pharmacology and Pharmacoepidemiology, Internal Medicine IX, Heidelberg University, Medical Faculty Heidelberg / Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Source: Fluids and barriers of the CNS [Fluids Barriers CNS] 2026 Apr 10; Vol. 23 (1). Date of Electronic Publication: 2026 Apr 10.
Publication Type: Journal Article
Journal Info: Publisher: Biomed Central Country of Publication: England NLM ID: 101553157 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-8118 (Electronic) Linking ISSN: 20458118 NLM ISO Abbreviation: Fluids Barriers CNS Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Bay+C%22">Bay C</searchLink>; Department of Clinical Pharmacology and Pharmacoepidemiology, Internal Medicine IX, Heidelberg University, Medical Faculty Heidelberg / Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Mühlberg+E%22">Mühlberg E</searchLink>; Department of Nuclear Medicine, Heidelberg University, Medical Faculty Heidelberg / Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.; Department of Pharmaceutical Technology and Biopharmacy, Institute for Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 329, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Uhl+P%22">Uhl P</searchLink>; Department of Pharmaceutical Technology and Biopharmacy, Institute for Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 329, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Stingl+JC%22">Stingl JC</searchLink>; Department of Clinical Pharmacology and Pharmacoepidemiology, Internal Medicine IX, Heidelberg University, Medical Faculty Heidelberg / Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Bajraktari-Sylejmani+G%22">Bajraktari-Sylejmani G</searchLink>; Department of Clinical Pharmacology and Pharmacoepidemiology, Internal Medicine IX, Heidelberg University, Medical Faculty Heidelberg / Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Burhenne+J%22">Burhenne J</searchLink>; Department of Clinical Pharmacology and Pharmacoepidemiology, Internal Medicine IX, Heidelberg University, Medical Faculty Heidelberg / Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Weiss+J%22">Weiss J</searchLink>; Department of Clinical Pharmacology and Pharmacoepidemiology, Internal Medicine IX, Heidelberg University, Medical Faculty Heidelberg / Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany. johanna.weiss@med.uni-heidelberg.de.<br /><searchLink fieldCode="AU" term="%22Sauter+M%22">Sauter M</searchLink>; Department of Clinical Pharmacology and Pharmacoepidemiology, Internal Medicine IX, Heidelberg University, Medical Faculty Heidelberg / Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
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  Data: <searchLink fieldCode="JN" term="%22101553157%22">Fluids and barriers of the CNS</searchLink> [Fluids Barriers CNS] 2026 Apr 10; Vol. 23 (1). <i>Date of Electronic Publication: </i>2026 Apr 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Biomed+Central%22">Biomed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101553157 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2045-8118 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220458118%22">20458118 </searchLink><i>NLM ISO Abbreviation: </i>Fluids Barriers CNS <i>Subsets: </i>MEDLINE
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              Text: 2026 Apr 10
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