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PARP inhibition with olaparib and talazoparib for HER2-negative advanced breast cancer-Results from the prospective PRAEGNANT registry.

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Title: PARP inhibition with olaparib and talazoparib for HER2-negative advanced breast cancer-Results from the prospective PRAEGNANT registry.
Authors: Hörner M; Department of Gynecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany., Hartkopf A; Department of Women's Health, Tuebingen University, Tuebingen, Germany., John N; Department of Gynecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.; Biostatistics Unit, Erlangen University Hospital, Department of Gynecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany., Ziegler P; Department of Gynecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany., Häberle L; Department of Gynecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.; Biostatistics Unit, Erlangen University Hospital, Department of Gynecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany., Uhrig S; Department of Gynecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany., Goossens C; Department of Gynecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany., Amann N; Department of Gynecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany., Cieslik JP; Department of Gynecology and Obstetrics, Center of Integrated Oncology ABCD, Medical Faculty, Heinrich Heine University and University Hospital Düsseldorf, Düsseldorf, Germany., Tretschock LM; Department of Obstetrics and Gynecology, University Hospital Heidelberg, Heidelberg, Germany., Dannehl D; Department of Gynecology and Gynecologic Oncology, Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf, Medical Faculty and University Clinic of Cologne, University of Cologne, Cologne, Germany., Deutsch TM; Department of Obstetrics and Gynecology, University Hospital Heidelberg, Heidelberg, Germany., Dimpfl M; Department of Gynecology and Obstetrics, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Ehlert M; University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Eichstädt K; Department of Gynecology, University Hospital Halle, Halle, Germany., Englisch A; Department of Women's Health, Tuebingen University, Tuebingen, Germany., Köpke MB; Department of Obstetrics and Gynaecology, University Hospital Augsburg, Augsburg, Germany., Krückel A; Department of Gynecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany., Link T; Department of Gynecology and Obstetrics, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Müller A; Department of Women's Health, Tuebingen University, Tuebingen, Germany., Reinhardt K; Department of Gynecology, University Hospital Halle, Halle, Germany., Roth J; Department of Obstetrics and Gynecology, Caritas Hospital St. Josef, University Medical Center Regensburg,, University of Regensburg, Regensburg, Germany., Schäffler H; Department of Gynecology and Obstetrics, University Hospital Ulm, Ulm, Germany., Sych L; Department of Medical Oncology, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany., Tauber N; Department of Gynecology and Obstetrics, University Hospital Schleswig-Holstein, Campus Lübeck, Luebeck, Germany., Tegeler CM; Department of Women's Health, Tuebingen University, Tuebingen, Germany., Wichmann C; Department of Gynecology and Obstetrics, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Banys-Paluchowski M; Department of Gynecology and Obstetrics, University Hospital Schleswig-Holstein, Campus Lübeck, Luebeck, Germany., Princk H; Department of Gynecology and Obstetrics, University Hospital Schleswig-Holstein, Campus Lübeck, Luebeck, Germany., Rody A; Department of Gynecology and Obstetrics, University Hospital Schleswig-Holstein, Campus Lübeck, Luebeck, Germany., Brucker SY; Department of Women's Health, Tuebingen University, Tuebingen, Germany., Ditsch N; Department of Obstetrics and Gynaecology, University Hospital Augsburg, Augsburg, Germany., Ettl J; Department of Obstetrics and Gynecology, Klinikum Rechts Der Isar, Technical University of Munich, Munich, Germany.; Cancer Center Kempten/Allgäu (CCKA), Klinikum Kempten, Kempten, Germany., Fehm T; Department of Gynecology and Obstetrics, Center of Integrated Oncology ABCD, Medical Faculty, Heinrich Heine University and University Hospital Düsseldorf, Düsseldorf, Germany., Hack CC; Department of Gynecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany., Hadji P; Frankfurt Center for Bone Health and Endocrinology, Frankfurt Am Main, Germany., Hein A; Department of Gynecology, Klinikum Esslingen GmbH, Esslingen, Germany., Janni WW; Department of Gynecology and Obstetrics, University Hospital Ulm, Ulm, Germany., Kolberg HC; Department of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop, Germany., Lüftner D; Immanuel Hospital Märkische Schweiz & Immanuel Campus Rüdersdorf, Medical University of Brandenburg Theodor-Fontane, Rüdersdorf bei Berlin, Germany., Lux MP; Department of Gynecology and Obstetrics, Frauenklinik St. Louise, Paderborn, St. Josefs-Krankenhaus, Salzkotten, Vincenz Kliniken GmbH, Paderborn, Germany., Müller V; University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Taran FA; Department of Gynecology and Gynecologic Oncology, Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf, Medical Faculty and University Clinic of Cologne, University of Cologne, Cologne, Germany., Tesch H; Oncology Practice, Bethanien Hospital, Frankfurt am Main, Germany., Wallwiener D; Department of Women's Health, Tuebingen University, Tuebingen, Germany., Marmé F; Department of Gynecology and Obstetrics, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Seitz S; Department of Obstetrics and Gynecology, Caritas Hospital St. Josef, University Medical Center Regensburg,, University of Regensburg, Regensburg, Germany., Belleville E; ClinSol GmbH & Co. KG, Würzburg, Germany., Michel LL; Department of Medical Oncology, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Wallwiener M; Department of Gynecology, University Hospital Halle, Halle, Germany., Fasching PA; Department of Gynecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany. peter.fasching@uk-erlangen.de., Schneeweiss A; Department of Medical Oncology, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Maurer C; Department of Gynecology and Gynecologic Oncology and Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Source: NPJ breast cancer [NPJ Breast Cancer] 2026 Apr 11; Vol. 12 (1). Date of Electronic Publication: 2026 Apr 11.
Publication Type: Journal Article
Journal Info: Publisher: Breast Cancer Research Foundation Country of Publication: United States NLM ID: 101674891 Publication Model: Electronic Cited Medium: Print ISSN: 2374-4677 (Print) Linking ISSN: 23744677 NLM ISO Abbreviation: NPJ Breast Cancer Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:2374-4677
DOI:10.1038/s41523-026-00947-8