UVB induces DNA hypomethylation and cell activation in CD4+ T cells of systemic lupus erythematosus via miR-410 regulating GADD45A.

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Title: UVB induces DNA hypomethylation and cell activation in CD4+ T cells of systemic lupus erythematosus via miR-410 regulating GADD45A.
Authors: Cai Z; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, PR China; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China; Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei 230012, PR China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, Anhui 230012, PR China., Cheng ZL; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, PR China; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China; Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei 230012, PR China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, Anhui 230012, PR China., Tan YN; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, PR China; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China; Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei 230012, PR China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, Anhui 230012, PR China., Meng XW; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, PR China; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China; Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei 230012, PR China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, Anhui 230012, PR China., Jiang GG; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, PR China; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China; Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei 230012, PR China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, Anhui 230012, PR China., Lu ZY; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, PR China; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China; Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei 230012, PR China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, Anhui 230012, PR China., Jin L; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China., Sun XG; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China., Wang X; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China., Li-Sun; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China., Xiang-Yuan; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China., Li XX; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China., Li YW; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China., Jia XY; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, PR China; Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei 230012, PR China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, Anhui 230012, PR China. Electronic address: jiaxy@ahtcm.edu.cn., Zhang M; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China. Electronic address: doczhangmin@ustc.edu.cn.
Source: Cellular immunology [Cell Immunol] 2026 Jul; Vol. 425, pp. 105101. Date of Electronic Publication: 2026 Apr 10.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 1246405 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2163 (Electronic) Linking ISSN: 00088749 NLM ISO Abbreviation: Cell Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1090-2163
DOI:10.1016/j.cellimm.2026.105101