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UVB induces DNA hypomethylation and cell activation in CD4+ T cells of systemic lupus erythematosus via miR-410 regulating GADD45A.

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Title: UVB induces DNA hypomethylation and cell activation in CD4+ T cells of systemic lupus erythematosus via miR-410 regulating GADD45A.
Authors: Cai Z; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, PR China; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China; Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei 230012, PR China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, Anhui 230012, PR China., Cheng ZL; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, PR China; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China; Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei 230012, PR China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, Anhui 230012, PR China., Tan YN; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, PR China; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China; Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei 230012, PR China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, Anhui 230012, PR China., Meng XW; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, PR China; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China; Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei 230012, PR China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, Anhui 230012, PR China., Jiang GG; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, PR China; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China; Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei 230012, PR China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, Anhui 230012, PR China., Lu ZY; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, PR China; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China; Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei 230012, PR China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, Anhui 230012, PR China., Jin L; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China., Sun XG; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China., Wang X; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China., Li-Sun; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China., Xiang-Yuan; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China., Li XX; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China., Li YW; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China., Jia XY; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, PR China; Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei 230012, PR China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, Anhui 230012, PR China. Electronic address: jiaxy@ahtcm.edu.cn., Zhang M; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China. Electronic address: doczhangmin@ustc.edu.cn.
Source: Cellular immunology [Cell Immunol] 2026 Jul; Vol. 425, pp. 105101. Date of Electronic Publication: 2026 Apr 10.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 1246405 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2163 (Electronic) Linking ISSN: 00088749 NLM ISO Abbreviation: Cell Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
An: 41967432
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  Data: UVB induces DNA hypomethylation and cell activation in CD4<superscript>+</superscript> T cells of systemic lupus erythematosus via miR-410 regulating GADD45A.
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  Data: <searchLink fieldCode="AU" term="%22Cai+Z%22">Cai Z</searchLink>; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, PR China; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China; Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei 230012, PR China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, Anhui 230012, PR China.<br /><searchLink fieldCode="AU" term="%22Cheng+ZL%22">Cheng ZL</searchLink>; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, PR China; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China; Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei 230012, PR China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, Anhui 230012, PR China.<br /><searchLink fieldCode="AU" term="%22Tan+YN%22">Tan YN</searchLink>; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, PR China; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China; Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei 230012, PR China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, Anhui 230012, PR China.<br /><searchLink fieldCode="AU" term="%22Meng+XW%22">Meng XW</searchLink>; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, PR China; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China; Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei 230012, PR China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, Anhui 230012, PR China.<br /><searchLink fieldCode="AU" term="%22Jiang+GG%22">Jiang GG</searchLink>; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, PR China; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China; Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei 230012, PR China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, Anhui 230012, PR China.<br /><searchLink fieldCode="AU" term="%22Lu+ZY%22">Lu ZY</searchLink>; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, PR China; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China; Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei 230012, PR China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, Anhui 230012, PR China.<br /><searchLink fieldCode="AU" term="%22Jin+L%22">Jin L</searchLink>; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China.<br /><searchLink fieldCode="AU" term="%22Sun+XG%22">Sun XG</searchLink>; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China.<br /><searchLink fieldCode="AU" term="%22Li-Sun%22">Li-Sun</searchLink>; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China.<br /><searchLink fieldCode="AU" term="%22Xiang-Yuan%22">Xiang-Yuan</searchLink>; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China.<br /><searchLink fieldCode="AU" term="%22Li+XX%22">Li XX</searchLink>; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China.<br /><searchLink fieldCode="AU" term="%22Li+YW%22">Li YW</searchLink>; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China.<br /><searchLink fieldCode="AU" term="%22Jia+XY%22">Jia XY</searchLink>; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, PR China; Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei 230012, PR China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, Anhui 230012, PR China. Electronic address: jiaxy@ahtcm.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China. Electronic address: doczhangmin@ustc.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%221246405%22">Cellular immunology</searchLink> [Cell Immunol] 2026 Jul; Vol. 425, pp. 105101. <i>Date of Electronic Publication: </i>2026 Apr 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>1246405 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1090-2163 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200088749%22">00088749 </searchLink><i>NLM ISO Abbreviation: </i>Cell Immunol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.cellimm.2026.105101
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        Text: English
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        StartPage: 105101
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      – TitleFull: UVB induces DNA hypomethylation and cell activation in CD4+ T cells of systemic lupus erythematosus via miR-410 regulating GADD45A.
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              Text: 2026 Jul
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