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Annexin A3 potentiates lenvatinib resistance in hepatocellular carcinoma through multiple approaches amplified by a positive feedback loop.

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Title: Annexin A3 potentiates lenvatinib resistance in hepatocellular carcinoma through multiple approaches amplified by a positive feedback loop.
Authors: Zhu Y; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Pancreato-Biliary Surgery, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China., Huang Y; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Medical Oncology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China., Song M; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Pediatric Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China., Yang J; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Biotherapy, Sun Yat-sen University Cancer Center, Guangzhou, China., Zhao J; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Biotherapy, Sun Yat-sen University Cancer Center, Guangzhou, China., Tang Y; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Biotherapy, Sun Yat-sen University Cancer Center, Guangzhou, China., Ouyang D; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Biotherapy, Sun Yat-sen University Cancer Center, Guangzhou, China., Yang C; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Biotherapy, Sun Yat-sen University Cancer Center, Guangzhou, China., Chen Y; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Biotherapy, Sun Yat-sen University Cancer Center, Guangzhou, China., Wang Q; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Biotherapy, Sun Yat-sen University Cancer Center, Guangzhou, China., Li Y; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Biotherapy, Sun Yat-sen University Cancer Center, Guangzhou, China., He J; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Biotherapy, Sun Yat-sen University Cancer Center, Guangzhou, China., Chen H; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Biotherapy, Sun Yat-sen University Cancer Center, Guangzhou, China., Xiang T; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Biotherapy, Sun Yat-sen University Cancer Center, Guangzhou, China., Xia J; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China. xiajch@mail.sysu.edu.cn.; Department of Biotherapy, Sun Yat-sen University Cancer Center, Guangzhou, China. xiajch@mail.sysu.edu.cn., Pan Q; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China. panqzh3@mail.sysu.edu.cn.; Department of Biotherapy, Sun Yat-sen University Cancer Center, Guangzhou, China. panqzh3@mail.sysu.edu.cn.
Source: Cell death & disease [Cell Death Dis] 2026 Apr 13; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-4889
DOI:10.1038/s41419-026-08735-9