Rational design of Gi-biased CB1 agonist with reduced side effects.

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Bibliographic Details
Title: Rational design of Gi-biased CB1 agonist with reduced side effects.
Authors: Liao YY; Department of Neurology and Department of Psychiatry of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; Nanhu Brain-Computer Interface Institute, Hangzhou 311100, China; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Center of Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Liangzhu Laboratory, Zhejiang University, Hangzhou 310058, China., Che J; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China., Gao YT; Department of Neurology and Department of Psychiatry of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; Nanhu Brain-Computer Interface Institute, Hangzhou 311100, China; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Center of Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Liangzhu Laboratory, Zhejiang University, Hangzhou 310058, China., Xue J; Department of Pathology of Sir Run Run Shaw Hospital, Department of Pharmacology and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China., Li L; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China., Wu LL; Department of Neurology and Department of Psychiatry of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; Nanhu Brain-Computer Interface Institute, Hangzhou 311100, China; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Center of Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Liangzhu Laboratory, Zhejiang University, Hangzhou 310058, China., Hu JX; Department of Neurology and Department of Psychiatry of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; Nanhu Brain-Computer Interface Institute, Hangzhou 311100, China; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Center of Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Liangzhu Laboratory, Zhejiang University, Hangzhou 310058, China., Hu MT; Department of Neurology and Department of Psychiatry of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; Nanhu Brain-Computer Interface Institute, Hangzhou 311100, China; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Center of Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Liangzhu Laboratory, Zhejiang University, Hangzhou 310058, China., Xie L; Department of Neurology and Department of Psychiatry of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; Nanhu Brain-Computer Interface Institute, Hangzhou 311100, China; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Center of Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Liangzhu Laboratory, Zhejiang University, Hangzhou 310058, China., Zhang H; Department of Pathology of Sir Run Run Shaw Hospital, Department of Pharmacology and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China., Shen DD; Department of Pathology of Sir Run Run Shaw Hospital, Department of Pharmacology and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China., Dong Y; Department of Pathology of Sir Run Run Shaw Hospital, Department of Pharmacology and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China., Zang S; Department of Pathology of Sir Run Run Shaw Hospital, Department of Pharmacology and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China., Zhang N; Department of Neurology and Department of Psychiatry of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; Nanhu Brain-Computer Interface Institute, Hangzhou 311100, China; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Center of Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Liangzhu Laboratory, Zhejiang University, Hangzhou 310058, China., Wang H; Department of Neurology and Department of Psychiatry of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Affiliated Mental Health Center and Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Zhejiang 310013, China., Zhang Y; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Center of Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Liangzhu Laboratory, Zhejiang University, Hangzhou 310058, China; Department of Pathology of Sir Run Run Shaw Hospital, Department of Pharmacology and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China. Electronic address: zhang_yan@zju.edu.cn., Dong X; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: dongxw@zju.edu.cn., Li XM; Department of Neurology and Department of Psychiatry of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; Nanhu Brain-Computer Interface Institute, Hangzhou 311100, China; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Center of Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Liangzhu Laboratory, Zhejiang University, Hangzhou 310058, China. Electronic address: lixm@zju.edu.cn.
Source: Cell [Cell] 2026 May 28; Vol. 189 (11), pp. 3432-3443.e16. Date of Electronic Publication: 2026 Apr 13.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1097-4172
DOI:10.1016/j.cell.2026.03.020