A phase 2, randomized, multicenter, double-blind, placebo-controlled trial of S-adenosyl methionine in participants with mild cognitive impairment or dementia due to Alzheimer's disease.
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| Title: | A phase 2, randomized, multicenter, double-blind, placebo-controlled trial of S-adenosyl methionine in participants with mild cognitive impairment or dementia due to Alzheimer's disease. |
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| Authors: | Holper S; Department of Medicine, Melbourne Brain Centre, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.; Genetics and Gene Regulation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; National Dementia Diagnostics Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia., Barnham KJ; National Dementia Diagnostics Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia., Churilov L; Department of Medicine, Melbourne Brain Centre, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia., Yates P; Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia.; Medical and Cognitive Research Unit, Department of Geriatric Medicine, Austin Health, Heidelberg, Victoria, Australia., Brodtmann A; Department of Neurology, Eastern Health, Monash University, Box Hill, Victoria, Australia., Johns S; Department of Geriatric Medicine, Modbury Hospital, Northern Adelaide Local Health Network, Adelaide, South Australia, Australia., Li QX; National Dementia Diagnostics Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia., Bhalala O; Department of Medicine, Melbourne Brain Centre, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.; Genetics and Gene Regulation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Chin KS; Department of Medicine, Melbourne Brain Centre, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.; Genetics and Gene Regulation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Loveland P; Department of Medicine, Melbourne Brain Centre, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.; Genetics and Gene Regulation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Yu JJ; Department of Medicine, Melbourne Brain Centre, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.; Genetics and Gene Regulation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Masters CL; National Dementia Diagnostics Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.; University of Melbourne, Parkville, Victoria, Australia., Watson R; Department of Medicine, Melbourne Brain Centre, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.; Genetics and Gene Regulation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Yassi N; Department of Medicine, Melbourne Brain Centre, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.; Genetics and Gene Regulation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; National Dementia Diagnostics Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia. |
| Source: | Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 Apr; Vol. 22 (4), pp. e71381. |
| Publication Type: | Journal Article; Multicenter Study; Randomized Controlled Trial; Clinical Trial, Phase II |
| Journal Info: | Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1552-5279 |
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| DOI: | 10.1002/alz.71381 |
