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A phase 2, randomized, multicenter, double-blind, placebo-controlled trial of S-adenosyl methionine in participants with mild cognitive impairment or dementia due to Alzheimer's disease.

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Title: A phase 2, randomized, multicenter, double-blind, placebo-controlled trial of S-adenosyl methionine in participants with mild cognitive impairment or dementia due to Alzheimer's disease.
Authors: Holper S; Department of Medicine, Melbourne Brain Centre, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.; Genetics and Gene Regulation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; National Dementia Diagnostics Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia., Barnham KJ; National Dementia Diagnostics Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia., Churilov L; Department of Medicine, Melbourne Brain Centre, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia., Yates P; Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia.; Medical and Cognitive Research Unit, Department of Geriatric Medicine, Austin Health, Heidelberg, Victoria, Australia., Brodtmann A; Department of Neurology, Eastern Health, Monash University, Box Hill, Victoria, Australia., Johns S; Department of Geriatric Medicine, Modbury Hospital, Northern Adelaide Local Health Network, Adelaide, South Australia, Australia., Li QX; National Dementia Diagnostics Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia., Bhalala O; Department of Medicine, Melbourne Brain Centre, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.; Genetics and Gene Regulation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Chin KS; Department of Medicine, Melbourne Brain Centre, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.; Genetics and Gene Regulation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Loveland P; Department of Medicine, Melbourne Brain Centre, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.; Genetics and Gene Regulation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Yu JJ; Department of Medicine, Melbourne Brain Centre, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.; Genetics and Gene Regulation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Masters CL; National Dementia Diagnostics Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.; University of Melbourne, Parkville, Victoria, Australia., Watson R; Department of Medicine, Melbourne Brain Centre, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.; Genetics and Gene Regulation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Yassi N; Department of Medicine, Melbourne Brain Centre, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.; Genetics and Gene Regulation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; National Dementia Diagnostics Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 Apr; Vol. 22 (4), pp. e71381.
Publication Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Clinical Trial, Phase II
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A phase 2, randomized, multicenter, double-blind, placebo-controlled trial of S-adenosyl methionine in participants with mild cognitive impairment or dementia due to Alzheimer's disease.
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  Data: <searchLink fieldCode="AU" term="%22Holper+S%22">Holper S</searchLink>; Department of Medicine, Melbourne Brain Centre, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.; Genetics and Gene Regulation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; National Dementia Diagnostics Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Barnham+KJ%22">Barnham KJ</searchLink>; National Dementia Diagnostics Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Churilov+L%22">Churilov L</searchLink>; Department of Medicine, Melbourne Brain Centre, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Yates+P%22">Yates P</searchLink>; Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia.; Medical and Cognitive Research Unit, Department of Geriatric Medicine, Austin Health, Heidelberg, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Brodtmann+A%22">Brodtmann A</searchLink>; Department of Neurology, Eastern Health, Monash University, Box Hill, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Johns+S%22">Johns S</searchLink>; Department of Geriatric Medicine, Modbury Hospital, Northern Adelaide Local Health Network, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Li+QX%22">Li QX</searchLink>; National Dementia Diagnostics Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Bhalala+O%22">Bhalala O</searchLink>; Department of Medicine, Melbourne Brain Centre, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.; Genetics and Gene Regulation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Chin+KS%22">Chin KS</searchLink>; Department of Medicine, Melbourne Brain Centre, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.; Genetics and Gene Regulation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Loveland+P%22">Loveland P</searchLink>; Department of Medicine, Melbourne Brain Centre, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.; Genetics and Gene Regulation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Yu+JJ%22">Yu JJ</searchLink>; Department of Medicine, Melbourne Brain Centre, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.; Genetics and Gene Regulation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Masters+CL%22">Masters CL</searchLink>; National Dementia Diagnostics Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.; University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Watson+R%22">Watson R</searchLink>; Department of Medicine, Melbourne Brain Centre, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.; Genetics and Gene Regulation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Yassi+N%22">Yassi N</searchLink>; Department of Medicine, Melbourne Brain Centre, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.; Genetics and Gene Regulation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; National Dementia Diagnostics Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.
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  Data: <searchLink fieldCode="JN" term="%22101231978%22">Alzheimer's & dementia : the journal of the Alzheimer's Association</searchLink> [Alzheimers Dement] 2026 Apr; Vol. 22 (4), pp. e71381.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22John+Wiley+%26+Sons%2C+Ltd%22">John Wiley & Sons, Ltd </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101231978 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1552-5279 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215525260%22">15525260 </searchLink><i>NLM ISO Abbreviation: </i>Alzheimers Dement <i>Subsets: </i>MEDLINE
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        Value: 10.1002/alz.71381
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        Text: English
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              Text: 2026 Apr
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