Extensive peripheral immunoglobulin repertoire analyses in people with multiple sclerosis reveal disease-specific signatures and distinct treatment effects of disease modifying drugs.

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Title: Extensive peripheral immunoglobulin repertoire analyses in people with multiple sclerosis reveal disease-specific signatures and distinct treatment effects of disease modifying drugs.
Authors: Vasilenko N; Hertie-Institute for Clinical Brain Research, Eberhard-Karls University of Tübingen, Tübingen, Germany., Ruschil C; Hertie-Institute for Clinical Brain Research, Eberhard-Karls University of Tübingen, Tübingen, Germany.; Department of Neurology & Stroke, Eberhard-Karls University of Tübingen, Tübingen, Germany., Stadelmaier J; Department for Computer Science, Biomedical Data Science, Eberhard-Karls University of Tübingen, Tübingen, Germany.; Quantitative Biology Center (QBiC), Eberhard-Karls University of Tübingen, Tübingen, Germany., Tieck MP; Hertie-Institute for Clinical Brain Research, Eberhard-Karls University of Tübingen, Tübingen, Germany.; Department of Neurology & Stroke, Eberhard-Karls University of Tübingen, Tübingen, Germany., Schembecker S; Hertie-Institute for Clinical Brain Research, Eberhard-Karls University of Tübingen, Tübingen, Germany., Owens GP; Departments of Neurology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, USA., Bennett JL; Departments of Neurology and Ophthalmology, Programs in Neuroscience and Immunology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, USA., Berthele A; Department of Neurology, School of Medicine and Health, Technical University of Munich, Munich, Germany., Ziemann U; Hertie-Institute for Clinical Brain Research, Eberhard-Karls University of Tübingen, Tübingen, Germany.; Department of Neurology & Stroke, Eberhard-Karls University of Tübingen, Tübingen, Germany., Poli S; Hertie-Institute for Clinical Brain Research, Eberhard-Karls University of Tübingen, Tübingen, Germany.; Department of Neurology & Stroke, Eberhard-Karls University of Tübingen, Tübingen, Germany., Snaidero N; Hertie-Institute for Clinical Brain Research, Eberhard-Karls University of Tübingen, Tübingen, Germany., Nahnsen S; Department for Computer Science, Biomedical Data Science, Eberhard-Karls University of Tübingen, Tübingen, Germany.; Quantitative Biology Center (QBiC), Eberhard-Karls University of Tübingen, Tübingen, Germany., Jarboui MA; Core Facility for Medical Bioanalytics (CFMB), Eberhard Karls University of Tübingen, Tübingen, Germany., Bichmann L; Center for Systems and Engineering Immunology, Yale University, New Haven, USA., Gabernet G; Department of Pathology, Yale School of Medicine, New Haven, USA., Kowarik MC; Hertie-Institute for Clinical Brain Research, Eberhard-Karls University of Tübingen, Tübingen, Germany. markus.kowarik@uni-tuebingen.de.; Department of Neurology & Stroke, Eberhard-Karls University of Tübingen, Tübingen, Germany. markus.kowarik@uni-tuebingen.de.
Source: Journal of neuroinflammation [J Neuroinflammation] 2026 Apr 14; Vol. 23 (1). Date of Electronic Publication: 2026 Apr 14.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-2094 (Electronic) Linking ISSN: 17422094 NLM ISO Abbreviation: J Neuroinflammation Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1742-2094
DOI:10.1186/s12974-026-03735-0