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Real-world effectiveness and tolerability of highly purified cannabidiol in patients with monogenic developmental and epileptic encephalopathies with highly active epilepsy.

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Title: Real-world effectiveness and tolerability of highly purified cannabidiol in patients with monogenic developmental and epileptic encephalopathies with highly active epilepsy.
Authors: Cerulli Irelli E; Department of Human Neurosciences, Sapienza University, Rome, Italy. Electronic address: emanueleci@hotmail.it., Mazzeo A; Department of Human Neurosciences, Sapienza University, Rome, Italy., Caraballo RH; Department of Neurology, Hospital de Pediatría 'Prof. Dr. Juan P Garrahan', Buenos Aires, Argentina., Perulli M; Pediatric Neurology and Psychiatric Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., Moloney PB; Department of Neurology, Mater Misericordiae University Hospital, Dublin, Ireland., Peña-Ceballos J; Department of Neurology, Beaumont Hospital, Dublin, Ireland., Simeone N; Department of Neuroscience, Reproductive Sciences and Odontostomatology, Federico II University of Naples, Naples, Italy., Mieszczanek TS; Danish Epilepsy Centre, Member of the European Reference Network (ERN) for Rare and Complex Epilepsies (EpiCARE), Dianalund, Denmark., Marini L; Department of Clinical and Experimental Medicine, University of Pisa 56100 Pisa, Italy., Licchetta L; IRCCS Istituto delle Scienze Neurologiche di Bologna, Member of the European Reference Network (ERN) for Rare and Complex Epilepsies (EpiCARE), Bologna, Italy., De Giorgis V; Brain and Behavioral Sciences Department, University of Pavia, Pavia, Italy; Childhood and Adolescence Epilepsy Center, Department of Child Neurology and Psychiatry, IRCCS Mondino Foundation, ERN EpiCARE Full Member, Pavia, Italy., Reyes Valenzuela G; Department of Neurology, Hospital de Pediatría 'Prof. Dr. Juan P Garrahan', Buenos Aires, Argentina., Casellato S; Department of Woman's and Child's Health, Child Neuropsichiatry Unit, Center of Pediatric Epilepsies, AOU Sassari, University of Sassari, Italy., Cesaroni E; Child Neurology and Psychiatric Unit, Pediatric Hospital G. Salesi, Azienda Ospedaliero-Universitaria delle Marche, Ancona, Italy., Operto FF; Department of Science of Health, School of Medicine, University of Catanzaro, Catanzaro, Italy., Domínguez-Carral J; Epilepsy Unit, Department of Child Neurology, Institut de Recerca Sant Joan de Déu, Member of the European Reference Network (ERN) for rare and complex epilepsies (EpiCARE), Barcelona, Spain., Ramírez-Camacho A; Epilepsy Unit, Department of Child Neurology, Institut de Recerca Sant Joan de Déu, Member of the European Reference Network (ERN) for rare and complex epilepsies (EpiCARE), Barcelona, Spain., Ferretti A; Department of Neuroscience, Mental Health & Sense Organs (NESMOS), Faculty of Medicine & Psychology, Sant'Andrea Hospital, 00198 Rome, Italy., Santangelo G; Child Neuropsychiatry Department, ISMEP-ARNAS Civico, 90100 Palermo, Italy., Aledo-Serrano A; Epilepsy Unit, Clinical Neurosciences Department, Blua Sanitas Valdebebas Hospital, Madrid, Spain., Rüegger A; Department of Neuropediatrics, University Children's Hospital Zurich, Zurich, Switzerland., Mancardi MM; IRCCS Istituto Giannina Gaslini, Member of the European Reference Network (ERN) for rare and complex epilepsies (EpiCARE), Genoa, Italy., Prato G; IRCCS Istituto Giannina Gaslini, Member of the European Reference Network (ERN) for rare and complex epilepsies (EpiCARE), Genoa, Italy., Riva A; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy., Bergonzini L; IRCCS Istituto delle Scienze Neurologiche di Bologna, Member of the European Reference Network (ERN) for Rare and Complex Epilepsies (EpiCARE), Bologna, Italy; Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum - University of Bologna, Bologna, Italy., Cordelli DM; IRCCS Istituto delle Scienze Neurologiche di Bologna, Member of the European Reference Network (ERN) for Rare and Complex Epilepsies (EpiCARE), Bologna, Italy; Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum - University of Bologna, Bologna, Italy., Bonanni P; Scientific Institute IRCCS E.Medea, Epilepsy and Clinical Neurophysiology Unit, Conegliano 31015, Italy., Bisulli F; IRCCS Istituto delle Scienze Neurologiche di Bologna, Member of the European Reference Network (ERN) for Rare and Complex Epilepsies (EpiCARE), Bologna, Italy; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy., Di Gennaro G; IRCCS 'Neuromed', Pozzilli 86077 Isernia, Italy., Matricardi S; Department of Pediatrics, University of Chieti-Pescara, 66100 Chieti, Italy., Striano P; IRCCS Istituto Giannina Gaslini, Member of the European Reference Network (ERN) for rare and complex epilepsies (EpiCARE), Genoa, Italy; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy., Delanty N; Department of Neurology, Beaumont Hospital, Dublin, Ireland; School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland; Research Ireland FutureNeuro Centre, Dublin, Ireland., Marini C; Child Neurology and Psychiatric Unit, Pediatric Hospital G. Salesi, Azienda Ospedaliero-Universitaria delle Marche, Ancona, Italy., Battaglia DI; Pediatric Neurology and Psychiatric Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., Di Bonaventura C; Department of Human Neurosciences, Sapienza University, Rome, Italy., Ramantani G; Department of Neuropediatrics, University Children's Hospital Zurich, Zurich, Switzerland., Gardella E; Danish Epilepsy Centre, Member of the European Reference Network (ERN) for Rare and Complex Epilepsies (EpiCARE), Dianalund, Denmark; University of Southern Denmark, Odense, Denmark., Orsini A; Department of Clinical and Experimental Medicine, University of Pisa 56100 Pisa, Italy., Coppola A; Department of Neuroscience, Reproductive Sciences and Odontostomatology, Federico II University of Naples, Naples, Italy.
Corporate Authors: GENE-CBD study group
Source: Epilepsy & behavior : E&B [Epilepsy Behav] 2026 Jul; Vol. 180, pp. 111036. Date of Electronic Publication: 2026 Apr 14.
Publication Type: Journal Article
Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 100892858 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-5069 (Electronic) Linking ISSN: 15255050 NLM ISO Abbreviation: Epilepsy Behav Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
FullText Text:
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  Data: Real-world effectiveness and tolerability of highly purified cannabidiol in patients with monogenic developmental and epileptic encephalopathies with highly active epilepsy.
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  Data: <searchLink fieldCode="AU" term="%22Cerulli+Irelli+E%22">Cerulli Irelli E</searchLink>; Department of Human Neurosciences, Sapienza University, Rome, Italy. Electronic address: emanueleci@hotmail.it.<br /><searchLink fieldCode="AU" term="%22Mazzeo+A%22">Mazzeo A</searchLink>; Department of Human Neurosciences, Sapienza University, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Caraballo+RH%22">Caraballo RH</searchLink>; Department of Neurology, Hospital de Pediatría 'Prof. Dr. Juan P Garrahan', Buenos Aires, Argentina.<br /><searchLink fieldCode="AU" term="%22Perulli+M%22">Perulli M</searchLink>; Pediatric Neurology and Psychiatric Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Moloney+PB%22">Moloney PB</searchLink>; Department of Neurology, Mater Misericordiae University Hospital, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Peña-Ceballos+J%22">Peña-Ceballos J</searchLink>; Department of Neurology, Beaumont Hospital, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Simeone+N%22">Simeone N</searchLink>; Department of Neuroscience, Reproductive Sciences and Odontostomatology, Federico II University of Naples, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Mieszczanek+TS%22">Mieszczanek TS</searchLink>; Danish Epilepsy Centre, Member of the European Reference Network (ERN) for Rare and Complex Epilepsies (EpiCARE), Dianalund, Denmark.<br /><searchLink fieldCode="AU" term="%22Marini+L%22">Marini L</searchLink>; Department of Clinical and Experimental Medicine, University of Pisa 56100 Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Licchetta+L%22">Licchetta L</searchLink>; IRCCS Istituto delle Scienze Neurologiche di Bologna, Member of the European Reference Network (ERN) for Rare and Complex Epilepsies (EpiCARE), Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22De+Giorgis+V%22">De Giorgis V</searchLink>; Brain and Behavioral Sciences Department, University of Pavia, Pavia, Italy; Childhood and Adolescence Epilepsy Center, Department of Child Neurology and Psychiatry, IRCCS Mondino Foundation, ERN EpiCARE Full Member, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Reyes+Valenzuela+G%22">Reyes Valenzuela G</searchLink>; Department of Neurology, Hospital de Pediatría 'Prof. Dr. Juan P Garrahan', Buenos Aires, Argentina.<br /><searchLink fieldCode="AU" term="%22Casellato+S%22">Casellato S</searchLink>; Department of Woman's and Child's Health, Child Neuropsichiatry Unit, Center of Pediatric Epilepsies, AOU Sassari, University of Sassari, Italy.<br /><searchLink fieldCode="AU" term="%22Cesaroni+E%22">Cesaroni E</searchLink>; Child Neurology and Psychiatric Unit, Pediatric Hospital G. Salesi, Azienda Ospedaliero-Universitaria delle Marche, Ancona, Italy.<br /><searchLink fieldCode="AU" term="%22Operto+FF%22">Operto FF</searchLink>; Department of Science of Health, School of Medicine, University of Catanzaro, Catanzaro, Italy.<br /><searchLink fieldCode="AU" term="%22Domínguez-Carral+J%22">Domínguez-Carral J</searchLink>; Epilepsy Unit, Department of Child Neurology, Institut de Recerca Sant Joan de Déu, Member of the European Reference Network (ERN) for rare and complex epilepsies (EpiCARE), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Ramírez-Camacho+A%22">Ramírez-Camacho A</searchLink>; Epilepsy Unit, Department of Child Neurology, Institut de Recerca Sant Joan de Déu, Member of the European Reference Network (ERN) for rare and complex epilepsies (EpiCARE), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Ferretti+A%22">Ferretti A</searchLink>; Department of Neuroscience, Mental Health & Sense Organs (NESMOS), Faculty of Medicine & Psychology, Sant'Andrea Hospital, 00198 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Santangelo+G%22">Santangelo G</searchLink>; Child Neuropsychiatry Department, ISMEP-ARNAS Civico, 90100 Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Aledo-Serrano+A%22">Aledo-Serrano A</searchLink>; Epilepsy Unit, Clinical Neurosciences Department, Blua Sanitas Valdebebas Hospital, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Rüegger+A%22">Rüegger A</searchLink>; Department of Neuropediatrics, University Children's Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mancardi+MM%22">Mancardi MM</searchLink>; IRCCS Istituto Giannina Gaslini, Member of the European Reference Network (ERN) for rare and complex epilepsies (EpiCARE), Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Prato+G%22">Prato G</searchLink>; IRCCS Istituto Giannina Gaslini, Member of the European Reference Network (ERN) for rare and complex epilepsies (EpiCARE), Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Riva+A%22">Riva A</searchLink>; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Bergonzini+L%22">Bergonzini L</searchLink>; IRCCS Istituto delle Scienze Neurologiche di Bologna, Member of the European Reference Network (ERN) for Rare and Complex Epilepsies (EpiCARE), Bologna, Italy; Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum - University of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Cordelli+DM%22">Cordelli DM</searchLink>; IRCCS Istituto delle Scienze Neurologiche di Bologna, Member of the European Reference Network (ERN) for Rare and Complex Epilepsies (EpiCARE), Bologna, Italy; Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum - University of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Bonanni+P%22">Bonanni P</searchLink>; Scientific Institute IRCCS E.Medea, Epilepsy and Clinical Neurophysiology Unit, Conegliano 31015, Italy.<br /><searchLink fieldCode="AU" term="%22Bisulli+F%22">Bisulli F</searchLink>; IRCCS Istituto delle Scienze Neurologiche di Bologna, Member of the European Reference Network (ERN) for Rare and Complex Epilepsies (EpiCARE), Bologna, Italy; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Gennaro+G%22">Di Gennaro G</searchLink>; IRCCS 'Neuromed', Pozzilli 86077 Isernia, Italy.<br /><searchLink fieldCode="AU" term="%22Matricardi+S%22">Matricardi S</searchLink>; Department of Pediatrics, University of Chieti-Pescara, 66100 Chieti, Italy.<br /><searchLink fieldCode="AU" term="%22Striano+P%22">Striano P</searchLink>; IRCCS Istituto Giannina Gaslini, Member of the European Reference Network (ERN) for rare and complex epilepsies (EpiCARE), Genoa, Italy; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Delanty+N%22">Delanty N</searchLink>; Department of Neurology, Beaumont Hospital, Dublin, Ireland; School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland; Research Ireland FutureNeuro Centre, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Marini+C%22">Marini C</searchLink>; Child Neurology and Psychiatric Unit, Pediatric Hospital G. 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