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Avapritinib achieves long-term disease control with favorable safety in patients with indolent systemic mastocytosis over 3 years.

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Title: Avapritinib achieves long-term disease control with favorable safety in patients with indolent systemic mastocytosis over 3 years.
Authors: Akin C; University of Michigan, Ann Arbor, Mich. Electronic address: cemakin@med.umich.edu., Sabato V; Department of Immunology, Allergology and Rheumatology, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium., Gotlib J; Stanford Cancer Institute/Stanford University School of Medicine, Stanford, Calif., Panse J; Department of Oncology, Hematology, Hemostaseology, and Stem Cell Transplantation, University Hospital Aachen, Medical Faculty, RWTH Aachen University, Aachen, Germany; Center for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf (ABCD), Aachen, Germany., Álvarez-Twose I; Institute of Mastocytosis Studies of Castilla-La Mancha, Virgen del Valle Hospital, Toledo, Spain., Radia DH; Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom., Livideanu CB; Department of Dermatology, Expert Center of Mastocytosis (CEREMAST), Toulouse University Hospital, Toulouse, France., Jurcic J; Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY., Elberink HO; Department of Allergology, University Medical Center, Groningen Research Institute Asthma and COPD, University of Groningen, Groningen, The Netherlands., Van Daele P; Department of Internal Medicine and Immunology, Erasmus Medical Center, Rotterdam, The Netherlands., Cerquozzi S; Department of Medicine, University of Calgary, Calgary, Alberta, Canada., Dybedal I; Departments of Hematology and Pharmacology, Oslo University Hospital, Oslo, Norway., Reiter A; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany., Pongdee T; Division of Allergic Diseases, Mayo Clinic, Rochester, Minn., Barete S; Unit of Dermatology, Reference Centre for Mastocytosis (CEREMAST) Pitié-Salpêtrière Hospital, AP-HP, Sorbonne Université, Paris, France., Ustun C; Division of Hematology, Oncology and Cell Therapy, Department of Internal Medicine, Section of Bone Marrow Transplantation and Cellular Therapy, Rush Medical College, Chicago, Ill., Schafhausen P; Department of Oncology, Hematology, and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Vadas P; Division of Clinical Immunology and Allergy, Department of Medicine, St Michael's Hospital University of Toronto, Toronto, Ontario, Canada., Bose P; Division of Cancer Medicine, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Tex., DeAngelo DJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Mass., Rein L; Department of Medicine, Duke University, School of Medicine, Durham, NC., Vachhani P; Department of Medicine, University of Alabama at Birmingham, Birmingham, Ala., Triggiani M; Division of Allergy and Clinical Immunology, University of Salerno, Salerno, Italy., Bonadonna P; Allergy Unit and Asthma Center, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy., Hartmann K; Division of Allergy, Department of Dermatology, University Hospital Basel and University of Basel, Basel, Switzerland; Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland; Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland., Broesby-Olsen S; Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark., Mattsson M; Department of Hematology, Uppsala University Hospital and Department of Immunology, Genetics and Pathology, Uppsala, Sweden., George TI; Department of Pathology, University of Utah, Salt Lake City, Utah., Shomali W; School of Medicine Stanford University School of Medicine, Stanford, Calif., Giannetti M; Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass., Siebenhaar F; Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany., Lin HM; Blueprint Medicines Corporation, Cambridge, Mass., Bidollari I; Blueprint Medicines Corporation, Cambridge, Mass., Lampson B; Blueprint Medicines Corporation, Cambridge, Mass., Hong J; Blueprint Medicines Corporation, Cambridge, Mass., Doyle A; Blueprint Medicines Corporation, Cambridge, Mass., Tashi T; Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah., Castells M; Division of Allergy and Clinical Immunology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
Source: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2026 Apr 14. Date of Electronic Publication: 2026 Apr 14.
Publication Type: Journal Article
Journal Info: Publisher: Mosby Country of Publication: United States NLM ID: 1275002 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6825 (Electronic) Linking ISSN: 00916749 NLM ISO Abbreviation: J Allergy Clin Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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  Data: Avapritinib achieves long-term disease control with favorable safety in patients with indolent systemic mastocytosis over 3 years.
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  Data: <searchLink fieldCode="AU" term="%22Akin+C%22">Akin C</searchLink>; University of Michigan, Ann Arbor, Mich. Electronic address: cemakin@med.umich.edu.<br /><searchLink fieldCode="AU" term="%22Sabato+V%22">Sabato V</searchLink>; Department of Immunology, Allergology and Rheumatology, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Gotlib+J%22">Gotlib J</searchLink>; Stanford Cancer Institute/Stanford University School of Medicine, Stanford, Calif.<br /><searchLink fieldCode="AU" term="%22Panse+J%22">Panse J</searchLink>; Department of Oncology, Hematology, Hemostaseology, and Stem Cell Transplantation, University Hospital Aachen, Medical Faculty, RWTH Aachen University, Aachen, Germany; Center for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf (ABCD), Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Álvarez-Twose+I%22">Álvarez-Twose I</searchLink>; Institute of Mastocytosis Studies of Castilla-La Mancha, Virgen del Valle Hospital, Toledo, Spain.<br /><searchLink fieldCode="AU" term="%22Radia+DH%22">Radia DH</searchLink>; Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Livideanu+CB%22">Livideanu CB</searchLink>; Department of Dermatology, Expert Center of Mastocytosis (CEREMAST), Toulouse University Hospital, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Jurcic+J%22">Jurcic J</searchLink>; Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Elberink+HO%22">Elberink HO</searchLink>; Department of Allergology, University Medical Center, Groningen Research Institute Asthma and COPD, University of Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Van+Daele+P%22">Van Daele P</searchLink>; Department of Internal Medicine and Immunology, Erasmus Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Cerquozzi+S%22">Cerquozzi S</searchLink>; Department of Medicine, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Dybedal+I%22">Dybedal I</searchLink>; Departments of Hematology and Pharmacology, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Reiter+A%22">Reiter A</searchLink>; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Pongdee+T%22">Pongdee T</searchLink>; Division of Allergic Diseases, Mayo Clinic, Rochester, Minn.<br /><searchLink fieldCode="AU" term="%22Barete+S%22">Barete S</searchLink>; Unit of Dermatology, Reference Centre for Mastocytosis (CEREMAST) Pitié-Salpêtrière Hospital, AP-HP, Sorbonne Université, Paris, France.<br /><searchLink fieldCode="AU" term="%22Ustun+C%22">Ustun C</searchLink>; Division of Hematology, Oncology and Cell Therapy, Department of Internal Medicine, Section of Bone Marrow Transplantation and Cellular Therapy, Rush Medical College, Chicago, Ill.<br /><searchLink fieldCode="AU" term="%22Schafhausen+P%22">Schafhausen P</searchLink>; Department of Oncology, Hematology, and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Vadas+P%22">Vadas P</searchLink>; Division of Clinical Immunology and Allergy, Department of Medicine, St Michael's Hospital University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Bose+P%22">Bose P</searchLink>; Division of Cancer Medicine, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Tex.<br /><searchLink fieldCode="AU" term="%22DeAngelo+DJ%22">DeAngelo DJ</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Mass.<br /><searchLink fieldCode="AU" term="%22Rein+L%22">Rein L</searchLink>; Department of Medicine, Duke University, School of Medicine, Durham, NC.<br /><searchLink fieldCode="AU" term="%22Vachhani+P%22">Vachhani P</searchLink>; Department of Medicine, University of Alabama at Birmingham, Birmingham, Ala.<br /><searchLink fieldCode="AU" term="%22Triggiani+M%22">Triggiani M</searchLink>; Division of Allergy and Clinical Immunology, University of Salerno, Salerno, Italy.<br /><searchLink fieldCode="AU" term="%22Bonadonna+P%22">Bonadonna P</searchLink>; Allergy Unit and Asthma Center, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Hartmann+K%22">Hartmann K</searchLink>; Division of Allergy, Department of Dermatology, University Hospital Basel and University of Basel, Basel, Switzerland; Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland; Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Broesby-Olsen+S%22">Broesby-Olsen S</searchLink>; Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Mattsson+M%22">Mattsson M</searchLink>; Department of Hematology, Uppsala University Hospital and Department of Immunology, Genetics and Pathology, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22George+TI%22">George TI</searchLink>; Department of Pathology, University of Utah, Salt Lake City, Utah.<br /><searchLink fieldCode="AU" term="%22Shomali+W%22">Shomali W</searchLink>; School of Medicine Stanford University School of Medicine, Stanford, Calif.<br /><searchLink fieldCode="AU" term="%22Giannetti+M%22">Giannetti M</searchLink>; Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.<br /><searchLink fieldCode="AU" term="%22Siebenhaar+F%22">Siebenhaar F</searchLink>; Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Lin+HM%22">Lin HM</searchLink>; Blueprint Medicines Corporation, Cambridge, Mass.<br /><searchLink fieldCode="AU" term="%22Bidollari+I%22">Bidollari I</searchLink>; Blueprint Medicines Corporation, Cambridge, Mass.<br /><searchLink fieldCode="AU" term="%22Lampson+B%22">Lampson B</searchLink>; Blueprint Medicines Corporation, Cambridge, Mass.<br /><searchLink fieldCode="AU" term="%22Hong+J%22">Hong J</searchLink>; Blueprint Medicines Corporation, Cambridge, Mass.<br /><searchLink fieldCode="AU" term="%22Doyle+A%22">Doyle A</searchLink>; Blueprint Medicines Corporation, Cambridge, Mass.<br /><searchLink fieldCode="AU" term="%22Tashi+T%22">Tashi T</searchLink>; Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah.<br /><searchLink fieldCode="AU" term="%22Castells+M%22">Castells M</searchLink>; Division of Allergy and Clinical Immunology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
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  Data: <searchLink fieldCode="JN" term="%221275002%22">The Journal of allergy and clinical immunology</searchLink> [J Allergy Clin Immunol] 2026 Apr 14. <i>Date of Electronic Publication: </i>2026 Apr 14.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Mosby%22">Mosby </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>1275002 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1097-6825 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200916749%22">00916749 </searchLink><i>NLM ISO Abbreviation: </i>J Allergy Clin Immunol <i>Subsets: </i>MEDLINE
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