The archaeal genetic code with all UAG codons as pyrrolysine might be an ancestral and not derived trait: the non-monophyletic origin of the genetic code.

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Title: The archaeal genetic code with all UAG codons as pyrrolysine might be an ancestral and not derived trait: the non-monophyletic origin of the genetic code.
Authors: Di Giulio M; The Ionian School, Early Evolution of Life Department, Genetic Code and tRNA Origin Laboratory, Via Roma 19, Alfedena, L'Aquila, 67030, Italy. Electronic address: massimodigiulio1952@gmail.com.
Source: Bio Systems [Biosystems] 2026 May; Vol. 263, pp. 105787. Date of Electronic Publication: 2026 Apr 14.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 0430773 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8324 (Electronic) Linking ISSN: 03032647 NLM ISO Abbreviation: Biosystems Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1872-8324
DOI:10.1016/j.biosystems.2026.105787