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An evolution-conserved allosteric network in human tubulin governs paclitaxel efficacy.

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Bibliographic Details
Title: An evolution-conserved allosteric network in human tubulin governs paclitaxel efficacy.
Authors: Luo J; School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Khoo CJ; School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Chen W; School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Liu Z; Department of Chemistry, Faculty of Science, The University of Hong Kong, Hong Kong, China., Li B; School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Lau WS; School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Li XD; Department of Chemistry, Faculty of Science, The University of Hong Kong, Hong Kong, China., Ti SC; School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China. jeffti@hku.hk.
Source: Nature chemical biology [Nat Chem Biol] 2026 Apr 15. Date of Electronic Publication: 2026 Apr 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1552-4469
DOI:10.1038/s41589-026-02204-2