Challenges and future directions for Mendelian randomization.

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Title: Challenges and future directions for Mendelian randomization.
Authors: Sanderson E; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK. eleanor.sanderson@bristol.ac.uk.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. eleanor.sanderson@bristol.ac.uk., Levin MG; Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA., Walker V; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.; Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Yuan S; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Badini I; Division of Psychiatry, University College London, London, UK., Dolce J; Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Mahida KJ; Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Harvard University, Cambridge, MA, USA., Nho JW; Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Warren Alpert Medical School, Brown University, Providence, RI, USA., Pingault JB; Department of Clinical, Educational, and Health Psychology, Division of Psychology and Language Sciences, University College London, London, UK., Damrauer SM; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA. scott.damrauer@pennmedicine.upenn.edu.; Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. scott.damrauer@pennmedicine.upenn.edu., Hemani G; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK. g.hemani@bristol.ac.uk.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. g.hemani@bristol.ac.uk., Davies NM; Division of Psychiatry, University College London, London, UK. neil.m.davies@ucl.ac.uk.; Department of Statistical Science, University College London, London, UK. neil.m.davies@ucl.ac.uk.; Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway. neil.m.davies@ucl.ac.uk.
Source: Nature genetics [Nat Genet] 2026 May; Vol. 58 (5), pp. 984-994. Date of Electronic Publication: 2026 Apr 15.
Publication Type: Journal Article; Review
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1546-1718
DOI:10.1038/s41588-026-02546-6