Ancient DNA reveals pervasive directional selection across West Eurasia.

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Title: Ancient DNA reveals pervasive directional selection across West Eurasia.
Authors: Akbari A; Department of Genetics, Harvard Medical School, Boston, MA, USA. Ali_Akbari@fas.harvard.edu.; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA. Ali_Akbari@fas.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Ali_Akbari@fas.harvard.edu., Perry A; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Barton AR; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kariminejad M; Shamsipour Technical and Vocational College, Tehran, Iran., Gazal S; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Center for Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA, USA., Li Z; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Zeng Y; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Department of Biostatistics and Data Science, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Mittnik A; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.; Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany., Patterson N; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Mah M; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA., Zhou X; Department of Statistics and Data Science, Yale University, New Haven, CT, USA., Price AL; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Lander ES; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.; Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA., Pinhasi R; Department of Evolutionary Anthropology, University of Vienna, Vienna, Austria.; Human Evolution and Archaeological Sciences, University of Vienna, Vienna, Austria., Rohland N; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Mallick S; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA., Reich D; Department of Genetics, Harvard Medical School, Boston, MA, USA. reich@genetics.med.harvard.edu.; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA. reich@genetics.med.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. reich@genetics.med.harvard.edu.; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA. reich@genetics.med.harvard.edu.
Source: Nature [Nature] 2026 Jun; Vol. 654 (8118), pp. 419-428. Date of Electronic Publication: 2026 Apr 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Akbari+A%22">Akbari A</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA, USA. Ali_Akbari@fas.harvard.edu.; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA. Ali_Akbari@fas.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Ali_Akbari@fas.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Perry+A%22">Perry A</searchLink>; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Barton+AR%22">Barton AR</searchLink>; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kariminejad+M%22">Kariminejad M</searchLink>; Shamsipour Technical and Vocational College, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Gazal+S%22">Gazal S</searchLink>; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Center for Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Zeng+Y%22">Zeng Y</searchLink>; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Department of Biostatistics and Data Science, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Mittnik+A%22">Mittnik A</searchLink>; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.; Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Patterson+N%22">Patterson N</searchLink>; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mah+M%22">Mah M</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+X%22">Zhou X</searchLink>; Department of Statistics and Data Science, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Price+AL%22">Price AL</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lander+ES%22">Lander ES</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.; Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pinhasi+R%22">Pinhasi R</searchLink>; Department of Evolutionary Anthropology, University of Vienna, Vienna, Austria.; Human Evolution and Archaeological Sciences, University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Rohland+N%22">Rohland N</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mallick+S%22">Mallick S</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Reich+D%22">Reich D</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA, USA. reich@genetics.med.harvard.edu.; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA. reich@genetics.med.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. reich@genetics.med.harvard.edu.; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA. reich@genetics.med.harvard.edu.
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