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NF-κB signaling drives rapid skeletal muscle atrophy in patients with breast cancer: the cost of fighting cancer with chemotherapy.

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Title: NF-κB signaling drives rapid skeletal muscle atrophy in patients with breast cancer: the cost of fighting cancer with chemotherapy.
Authors: Mallard J; Exercise Physiology Laboratory, Institut Strauss, Strasbourg, France.; Biomedicine Research Center of Strasbourg (CRBS), UR 3072, 'Mitochondria, Oxidative Stress and Muscle Plasticity', University of Strasbourg, Strasbourg, France.; Faculty of Sport Sciences, European Center of Research, Teaching, Innovation and Exercise Physiology (CEERIPE), University of Strasbourg, Strasbourg, France., Debrut L; Biomedicine Research Center of Strasbourg (CRBS), UR 3072, 'Mitochondria, Oxidative Stress and Muscle Plasticity', University of Strasbourg, Strasbourg, France.; Faculty of Sport Sciences, European Center of Research, Teaching, Innovation and Exercise Physiology (CEERIPE), University of Strasbourg, Strasbourg, France., Hucteau E; Exercise Physiology Laboratory, Institut Strauss, Strasbourg, France.; Biomedicine Research Center of Strasbourg (CRBS), UR 3072, 'Mitochondria, Oxidative Stress and Muscle Plasticity', University of Strasbourg, Strasbourg, France.; Faculty of Sport Sciences, European Center of Research, Teaching, Innovation and Exercise Physiology (CEERIPE), University of Strasbourg, Strasbourg, France., Somme L; Exercise Physiology Laboratory, Institut Strauss, Strasbourg, France., Bischoff H; Exercise Physiology Laboratory, Institut Strauss, Strasbourg, France., Moinard-Butot F; Exercise Physiology Laboratory, Institut Strauss, Strasbourg, France., Coliat P; Pharmacy Department, Institut Strauss, Strasbourg, France., Bendjama A; Pharmacy Department, Institut Strauss, Strasbourg, France., Weltzer L; Exercise Physiology Laboratory, Institut Strauss, Strasbourg, France.; Biomedicine Research Center of Strasbourg (CRBS), UR 3072, 'Mitochondria, Oxidative Stress and Muscle Plasticity', University of Strasbourg, Strasbourg, France., Sharifi Tafreshi A; Exercise Physiology Laboratory, Institut Strauss, Strasbourg, France., Billand C; Biomedicine Research Center of Strasbourg (CRBS), UR 3072, 'Mitochondria, Oxidative Stress and Muscle Plasticity', University of Strasbourg, Strasbourg, France., Charlot A; INSERM, Institute for Translational Medicine and Liver Disease, UMR S1110, University of Strasbourg, Strasbourg, France., Boutonnet L; Biomedicine Research Center of Strasbourg (CRBS), UR 3072, 'Mitochondria, Oxidative Stress and Muscle Plasticity', University of Strasbourg, Strasbourg, France.; NeuroMyoGene Institute, CNRS UMR 5261, INSERM U1315, University of Lyon 1, Lyon, France., Laverny G; Institute of Genetic, Molecular and Cellular Biology (IGBMC), INSERM U1258, CNRS UMR 7104, University of Strasbourg, Strasbourg, France., Keime C; Institute of Genetic, Molecular and Cellular Biology (IGBMC), INSERM U1258, CNRS UMR 7104, University of Strasbourg, Strasbourg, France., Favret F; Biomedicine Research Center of Strasbourg (CRBS), UR 3072, 'Mitochondria, Oxidative Stress and Muscle Plasticity', University of Strasbourg, Strasbourg, France.; Faculty of Sport Sciences, European Center of Research, Teaching, Innovation and Exercise Physiology (CEERIPE), University of Strasbourg, Strasbourg, France., Schott R; Exercise Physiology Laboratory, Institut Strauss, Strasbourg, France., Pivot X; Exercise Physiology Laboratory, Institut Strauss, Strasbourg, France., Hureau TJ; Exercise Physiology Laboratory, Institut Strauss, Strasbourg, France.; Biomedicine Research Center of Strasbourg (CRBS), UR 3072, 'Mitochondria, Oxidative Stress and Muscle Plasticity', University of Strasbourg, Strasbourg, France.; Faculty of Sport Sciences, European Center of Research, Teaching, Innovation and Exercise Physiology (CEERIPE), University of Strasbourg, Strasbourg, France., Pagano AF; Exercise Physiology Laboratory, Institut Strauss, Strasbourg, France.; Biomedicine Research Center of Strasbourg (CRBS), UR 3072, 'Mitochondria, Oxidative Stress and Muscle Plasticity', University of Strasbourg, Strasbourg, France.; Faculty of Sport Sciences, European Center of Research, Teaching, Innovation and Exercise Physiology (CEERIPE), University of Strasbourg, Strasbourg, France.
Source: American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2026 May 01; Vol. 330 (5), pp. C1427-C1442. Date of Electronic Publication: 2026 Apr 16.
Publication Type: Journal Article
Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901225 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1563 (Electronic) Linking ISSN: 03636143 NLM ISO Abbreviation: Am J Physiol Cell Physiol Subsets: MEDLINE
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  Data: NF-κB signaling drives rapid skeletal muscle atrophy in patients with breast cancer: the cost of fighting cancer with chemotherapy.
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  Data: <searchLink fieldCode="AU" term="%22Mallard+J%22">Mallard J</searchLink>; Exercise Physiology Laboratory, Institut Strauss, Strasbourg, France.; Biomedicine Research Center of Strasbourg (CRBS), UR 3072, 'Mitochondria, Oxidative Stress and Muscle Plasticity', University of Strasbourg, Strasbourg, France.; Faculty of Sport Sciences, European Center of Research, Teaching, Innovation and Exercise Physiology (CEERIPE), University of Strasbourg, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Debrut+L%22">Debrut L</searchLink>; Biomedicine Research Center of Strasbourg (CRBS), UR 3072, 'Mitochondria, Oxidative Stress and Muscle Plasticity', University of Strasbourg, Strasbourg, France.; Faculty of Sport Sciences, European Center of Research, Teaching, Innovation and Exercise Physiology (CEERIPE), University of Strasbourg, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Hucteau+E%22">Hucteau E</searchLink>; Exercise Physiology Laboratory, Institut Strauss, Strasbourg, France.; Biomedicine Research Center of Strasbourg (CRBS), UR 3072, 'Mitochondria, Oxidative Stress and Muscle Plasticity', University of Strasbourg, Strasbourg, France.; Faculty of Sport Sciences, European Center of Research, Teaching, Innovation and Exercise Physiology (CEERIPE), University of Strasbourg, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Somme+L%22">Somme L</searchLink>; Exercise Physiology Laboratory, Institut Strauss, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Bischoff+H%22">Bischoff H</searchLink>; Exercise Physiology Laboratory, Institut Strauss, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Moinard-Butot+F%22">Moinard-Butot F</searchLink>; Exercise Physiology Laboratory, Institut Strauss, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Coliat+P%22">Coliat P</searchLink>; Pharmacy Department, Institut Strauss, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Bendjama+A%22">Bendjama A</searchLink>; Pharmacy Department, Institut Strauss, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Weltzer+L%22">Weltzer L</searchLink>; Exercise Physiology Laboratory, Institut Strauss, Strasbourg, France.; Biomedicine Research Center of Strasbourg (CRBS), UR 3072, 'Mitochondria, Oxidative Stress and Muscle Plasticity', University of Strasbourg, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Sharifi+Tafreshi+A%22">Sharifi Tafreshi A</searchLink>; Exercise Physiology Laboratory, Institut Strauss, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Billand+C%22">Billand C</searchLink>; Biomedicine Research Center of Strasbourg (CRBS), UR 3072, 'Mitochondria, Oxidative Stress and Muscle Plasticity', University of Strasbourg, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Charlot+A%22">Charlot A</searchLink>; INSERM, Institute for Translational Medicine and Liver Disease, UMR S1110, University of Strasbourg, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Boutonnet+L%22">Boutonnet L</searchLink>; Biomedicine Research Center of Strasbourg (CRBS), UR 3072, 'Mitochondria, Oxidative Stress and Muscle Plasticity', University of Strasbourg, Strasbourg, France.; NeuroMyoGene Institute, CNRS UMR 5261, INSERM U1315, University of Lyon 1, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Laverny+G%22">Laverny G</searchLink>; Institute of Genetic, Molecular and Cellular Biology (IGBMC), INSERM U1258, CNRS UMR 7104, University of Strasbourg, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Keime+C%22">Keime C</searchLink>; Institute of Genetic, Molecular and Cellular Biology (IGBMC), INSERM U1258, CNRS UMR 7104, University of Strasbourg, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Favret+F%22">Favret F</searchLink>; Biomedicine Research Center of Strasbourg (CRBS), UR 3072, 'Mitochondria, Oxidative Stress and Muscle Plasticity', University of Strasbourg, Strasbourg, France.; Faculty of Sport Sciences, European Center of Research, Teaching, Innovation and Exercise Physiology (CEERIPE), University of Strasbourg, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Schott+R%22">Schott R</searchLink>; Exercise Physiology Laboratory, Institut Strauss, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Pivot+X%22">Pivot X</searchLink>; Exercise Physiology Laboratory, Institut Strauss, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Hureau+TJ%22">Hureau TJ</searchLink>; Exercise Physiology Laboratory, Institut Strauss, Strasbourg, France.; Biomedicine Research Center of Strasbourg (CRBS), UR 3072, 'Mitochondria, Oxidative Stress and Muscle Plasticity', University of Strasbourg, Strasbourg, France.; Faculty of Sport Sciences, European Center of Research, Teaching, Innovation and Exercise Physiology (CEERIPE), University of Strasbourg, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Pagano+AF%22">Pagano AF</searchLink>; Exercise Physiology Laboratory, Institut Strauss, Strasbourg, France.; Biomedicine Research Center of Strasbourg (CRBS), UR 3072, 'Mitochondria, Oxidative Stress and Muscle Plasticity', University of Strasbourg, Strasbourg, France.; Faculty of Sport Sciences, European Center of Research, Teaching, Innovation and Exercise Physiology (CEERIPE), University of Strasbourg, Strasbourg, France.
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