Uttroside B, a US FDA-designated 'Orphan Drug', mitigates the development of hepatocellular carcinoma and its pulmonary metastasis via EGFR/ERK-mediated inhibition of SREBP-1 and STAT-3.
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| Title: | Uttroside B, a US FDA-designated 'Orphan Drug', mitigates the development of hepatocellular carcinoma and its pulmonary metastasis via EGFR/ERK-mediated inhibition of SREBP-1 and STAT-3. |
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| Authors: | Keerthana CK; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India.; Department of Biotechnology, University of Kerala, Thiruvananthapuram, India., Rayginia TP; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India.; Molecular Bioassay Laboratory, Institute of Advanced Virology, Thiruvananthapuram, India., Kalimuthu K; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India., Saha S; Regional Centre for Biotechnology, Faridabad, India., Haritha NH; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India., Nisthul Areekkara A; Department of Biotechnology and Microbiology, Thalassery Campus, Kannur University, Kannur, India., Swetha M; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India., Aiswarya SU; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India., Nath LR; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India.; Department of Pharmacognosy, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus, Kochi, India., Varma SS; Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram, India., Viswanathan A; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India., S J; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India., J S; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India., Js A; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India., Praveen A; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India., Jaikumar VS; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India., Sundaram S; Department of Pathology, Government Medical College, Kottayam, India., Anto NP; The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel., Maiti TK; Regional Centre for Biotechnology, Faridabad, India., Sadasivan C; Department of Biotechnology and Microbiology, Thalassery Campus, Kannur University, Kannur, India., Isakov N; The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel., Lankalapalli RS; Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram, India., Harikumar KB; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India., Anto RJ; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India. cs.coen@kerala.gov.in.; Molecular Bioassay Laboratory, Institute of Advanced Virology, Thiruvananthapuram, India. cs.coen@kerala.gov.in.; Centre of Excellence in Nutraceuticals, KSCSTE, Government of Kerala, Thiruvananthapuram, India. cs.coen@kerala.gov.in. |
| Source: | Cell death discovery [Cell Death Discov] 2026 Apr 16; Vol. 12 (1). Date of Electronic Publication: 2026 Apr 16. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2058-7716 |
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| DOI: | 10.1038/s41420-026-03055-5 |
