Uttroside B, a US FDA-designated 'Orphan Drug', mitigates the development of hepatocellular carcinoma and its pulmonary metastasis via EGFR/ERK-mediated inhibition of SREBP-1 and STAT-3.
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| Title: | Uttroside B, a US FDA-designated 'Orphan Drug', mitigates the development of hepatocellular carcinoma and its pulmonary metastasis via EGFR/ERK-mediated inhibition of SREBP-1 and STAT-3. |
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| Authors: | Keerthana CK; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India.; Department of Biotechnology, University of Kerala, Thiruvananthapuram, India., Rayginia TP; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India.; Molecular Bioassay Laboratory, Institute of Advanced Virology, Thiruvananthapuram, India., Kalimuthu K; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India., Saha S; Regional Centre for Biotechnology, Faridabad, India., Haritha NH; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India., Nisthul Areekkara A; Department of Biotechnology and Microbiology, Thalassery Campus, Kannur University, Kannur, India., Swetha M; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India., Aiswarya SU; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India., Nath LR; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India.; Department of Pharmacognosy, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus, Kochi, India., Varma SS; Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram, India., Viswanathan A; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India., S J; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India., J S; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India., Js A; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India., Praveen A; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India., Jaikumar VS; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India., Sundaram S; Department of Pathology, Government Medical College, Kottayam, India., Anto NP; The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel., Maiti TK; Regional Centre for Biotechnology, Faridabad, India., Sadasivan C; Department of Biotechnology and Microbiology, Thalassery Campus, Kannur University, Kannur, India., Isakov N; The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel., Lankalapalli RS; Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram, India., Harikumar KB; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India., Anto RJ; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India. cs.coen@kerala.gov.in.; Molecular Bioassay Laboratory, Institute of Advanced Virology, Thiruvananthapuram, India. cs.coen@kerala.gov.in.; Centre of Excellence in Nutraceuticals, KSCSTE, Government of Kerala, Thiruvananthapuram, India. cs.coen@kerala.gov.in. |
| Source: | Cell death discovery [Cell Death Discov] 2026 Apr 16; Vol. 12 (1). Date of Electronic Publication: 2026 Apr 16. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41991930 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Uttroside B, a US FDA-designated 'Orphan Drug', mitigates the development of hepatocellular carcinoma and its pulmonary metastasis via EGFR/ERK-mediated inhibition of SREBP-1 and STAT-3. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Keerthana+CK%22">Keerthana CK</searchLink>; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India.; Department of Biotechnology, University of Kerala, Thiruvananthapuram, India.<br /><searchLink fieldCode="AU" term="%22Rayginia+TP%22">Rayginia TP</searchLink>; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India.; Molecular Bioassay Laboratory, Institute of Advanced Virology, Thiruvananthapuram, India.<br /><searchLink fieldCode="AU" term="%22Kalimuthu+K%22">Kalimuthu K</searchLink>; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India.<br /><searchLink fieldCode="AU" term="%22Saha+S%22">Saha S</searchLink>; Regional Centre for Biotechnology, Faridabad, India.<br /><searchLink fieldCode="AU" term="%22Haritha+NH%22">Haritha NH</searchLink>; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India.<br /><searchLink fieldCode="AU" term="%22Nisthul+Areekkara+A%22">Nisthul Areekkara A</searchLink>; Department of Biotechnology and Microbiology, Thalassery Campus, Kannur University, Kannur, India.<br /><searchLink fieldCode="AU" term="%22Swetha+M%22">Swetha M</searchLink>; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India.<br /><searchLink fieldCode="AU" term="%22Aiswarya+SU%22">Aiswarya SU</searchLink>; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India.<br /><searchLink fieldCode="AU" term="%22Nath+LR%22">Nath LR</searchLink>; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India.; Department of Pharmacognosy, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus, Kochi, India.<br /><searchLink fieldCode="AU" term="%22Varma+SS%22">Varma SS</searchLink>; Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram, India.<br /><searchLink fieldCode="AU" term="%22Viswanathan+A%22">Viswanathan A</searchLink>; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India.<br /><searchLink fieldCode="AU" term="%22S+J%22">S J</searchLink>; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India.<br /><searchLink fieldCode="AU" term="%22J+S%22">J S</searchLink>; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India.<br /><searchLink fieldCode="AU" term="%22Js+A%22">Js A</searchLink>; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India.<br /><searchLink fieldCode="AU" term="%22Praveen+A%22">Praveen A</searchLink>; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India.<br /><searchLink fieldCode="AU" term="%22Jaikumar+VS%22">Jaikumar VS</searchLink>; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India.<br /><searchLink fieldCode="AU" term="%22Sundaram+S%22">Sundaram S</searchLink>; Department of Pathology, Government Medical College, Kottayam, India.<br /><searchLink fieldCode="AU" term="%22Anto+NP%22">Anto NP</searchLink>; The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.<br /><searchLink fieldCode="AU" term="%22Maiti+TK%22">Maiti TK</searchLink>; Regional Centre for Biotechnology, Faridabad, India.<br /><searchLink fieldCode="AU" term="%22Sadasivan+C%22">Sadasivan C</searchLink>; Department of Biotechnology and Microbiology, Thalassery Campus, Kannur University, Kannur, India.<br /><searchLink fieldCode="AU" term="%22Isakov+N%22">Isakov N</searchLink>; The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.<br /><searchLink fieldCode="AU" term="%22Lankalapalli+RS%22">Lankalapalli RS</searchLink>; Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram, India.<br /><searchLink fieldCode="AU" term="%22Harikumar+KB%22">Harikumar KB</searchLink>; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India.<br /><searchLink fieldCode="AU" term="%22Anto+RJ%22">Anto RJ</searchLink>; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India. cs.coen@kerala.gov.in.; Molecular Bioassay Laboratory, Institute of Advanced Virology, Thiruvananthapuram, India. cs.coen@kerala.gov.in.; Centre of Excellence in Nutraceuticals, KSCSTE, Government of Kerala, Thiruvananthapuram, India. cs.coen@kerala.gov.in. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101665035%22">Cell death discovery</searchLink> [Cell Death Discov] 2026 Apr 16; Vol. 12 (1). <i>Date of Electronic Publication: </i>2026 Apr 16. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101665035 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2058-7716 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220587716%22">20587716 </searchLink><i>NLM ISO Abbreviation: </i>Cell Death Discov <i>Subsets: </i>PubMed not MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41991930 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41420-026-03055-5 Languages: – Code: eng Text: English Titles: – TitleFull: Uttroside B, a US FDA-designated 'Orphan Drug', mitigates the development of hepatocellular carcinoma and its pulmonary metastasis via EGFR/ERK-mediated inhibition of SREBP-1 and STAT-3. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Keerthana CK – PersonEntity: Name: NameFull: Rayginia TP – PersonEntity: Name: NameFull: Kalimuthu K – PersonEntity: Name: NameFull: Saha S – PersonEntity: Name: NameFull: Haritha NH – PersonEntity: Name: NameFull: Nisthul Areekkara A – PersonEntity: Name: NameFull: Swetha M – PersonEntity: Name: NameFull: Aiswarya SU – PersonEntity: Name: NameFull: Nath LR – PersonEntity: Name: NameFull: Varma SS – PersonEntity: Name: NameFull: Viswanathan A – PersonEntity: Name: NameFull: S J – PersonEntity: Name: NameFull: J S – PersonEntity: Name: NameFull: Js A – PersonEntity: Name: NameFull: Praveen A – PersonEntity: Name: NameFull: Jaikumar VS – PersonEntity: Name: NameFull: Sundaram S – PersonEntity: Name: NameFull: Anto NP – PersonEntity: Name: NameFull: Maiti TK – PersonEntity: Name: NameFull: Sadasivan C – PersonEntity: Name: NameFull: Isakov N – PersonEntity: Name: NameFull: Lankalapalli RS – PersonEntity: Name: NameFull: Harikumar KB – PersonEntity: Name: NameFull: Anto RJ IsPartOfRelationships: – BibEntity: Dates: – D: 16 M: 04 Text: 2026 Apr 16 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 2058-7716 Numbering: – Type: volume Value: 12 – Type: issue Value: 1 Titles: – TitleFull: Cell death discovery Type: main |
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